Ignite Creation Date:
2024-07-17 @ 10:53 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06464393
Status:
RECRUITING
Last Update Posted:
2024-06-18
First Post:
2024-06-13
Brief Title:
Opioid-based Versus Opioid-free Endotracheal Intubation
Sponsor:
Aretaieion University Hospital
Organization:
Aretaieion University Hospital
Study Overview
Official Title:
The Effect of Opioid-free Anesthesia on Hemodynamic Response and Nociception Level Index During Laryngoscopy and Intubation
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study will be to investigate the effect of opioid-free induction versus opioid-based induction on hemodynamic response and nociception level index during elective operations
Detailed Description:
Laryngoscopy and intubation stimuli can cause a sustained sympathetic response manifested as hypertension and tachycardia Therefore preadministration of opioid medication aiming at blunting this hemodynamic response is common in everyday anesthetic practice
Opioid-based anesthesia is associated with side-effects such as respiratory depression postoperative nausea and vomiting and occasional induction of tolerance and hyperalgesia
Research in recent years has focused on the quest for non-opioid-based regimens opioid-sparing and opioid-free techniques Most of the relevant studies however focus on the advantages that opioid-free techniques bear on early and late postoperative patient recovery Literature on the effect of opioid-free techniques especially on laryngoscopy intubation and subsequent hemodynamic response
Therefore the aim of this study will be the comparison of the hemodynamic response to laryngoscopy and intubation between two groups of patients a group in which opioid medications will be administered before anesthetic induction and a group in which a combination of lidocaine dexmedetomidine and ketamine will be administered before anesthetic induction
Opioid-based anesthesia is associated with side-effects such as respiratory depression postoperative nausea and vomiting and occasional induction of tolerance and hyperalgesia
Research in recent years has focused on the quest for non-opioid-based regimens opioid-sparing and opioid-free techniques Most of the relevant studies however focus on the advantages that opioid-free techniques bear on early and late postoperative patient recovery Literature on the effect of opioid-free techniques especially on laryngoscopy intubation and subsequent hemodynamic response
Therefore the aim of this study will be the comparison of the hemodynamic response to laryngoscopy and intubation between two groups of patients a group in which opioid medications will be administered before anesthetic induction and a group in which a combination of lidocaine dexmedetomidine and ketamine will be administered before anesthetic induction
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None