Ignite Creation Date:
2024-07-17 @ 10:54 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06484738
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-03
First Post:
2024-06-26
Brief Title:
Spatially Resolved IBD Spatial Transcriptomics of Inflammatory Bowel Disease IBD
Sponsor:
IRCCS San Raffaele
Organization:
IRCCS San Raffaele
Study Overview
Official Title:
Spatially Resolved IBD Spatial Transcriptomics of Inflammatory Bowel Disease IBD
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this retrospective observational study is to obtain the spatial resolution of the entire intestinal fibrotic process through the technology STOmics Stereoseq For this study we will use surgical specimens from 8 UC e 8 CD previously collected for the already approved project IBD Biobank and stored at -80 C
Detailed Description:
This is a monocentric observational study in which we will use the biological material from surgery carried out for normal clinical practice and already stored at -80C
This project has as purpose
1 To unravel the changes in the intestine leading to complications in CD and UC patients In particular we aim to identify the cell populations their spatial organization interactions and specific transcriptional shifts leading the progression from healthy tissue to inflamed and from inflamed to fibrotic tissue We will be interested in producing a profile of Spatial transcriptomics of all areas of the surgical specimen
2 To compare the spatial organization and differential gene expression of tissue
This project has as purpose
1 To unravel the changes in the intestine leading to complications in CD and UC patients In particular we aim to identify the cell populations their spatial organization interactions and specific transcriptional shifts leading the progression from healthy tissue to inflamed and from inflamed to fibrotic tissue We will be interested in producing a profile of Spatial transcriptomics of all areas of the surgical specimen
2 To compare the spatial organization and differential gene expression of tissue
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None