Ignite Creation Date:
2024-07-17 @ 10:56 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06462768
Status:
RECRUITING
Last Update Posted:
2024-06-17
First Post:
2024-06-12
Brief Title:
Neutrophil Extracellular Traps in Different Forms of Systemic Sclerosis
Sponsor:
CHU de Reims
Organization:
CHU de Reims
Study Overview
Official Title:
Neutrophil Extracellular Traps in Systemic Sclerosis
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NETOSE
Brief Summary:
Systemic SClerosis SSC is a systemic disease characterized by limited or diffuse cutaneous sclerosis microangiopathy overproduction of autoantibodies and variable organ damage due to vasculopathy andor fibrosis The loss of self-tolerance is believed to be caused by the dysregulation of both innate and adaptive immune systems and may involve Reactive Oxygen Species ROS
Neutrophils are potent producers of ROS and may play a role in endothelial cells and fibrobasts dysfunction as in autoantibodies generation However their role in SSC pathogenesis remains to be determined Recent studies discovered abnormal regulation of Neutrophil Extracellular Traps NETs in other auto-immune diseases such as Systemic Lupus Erythematosus SLE NETs are web-like structures composed of chromatin backbones and granular molecules They are released by activated neutrophils through a process called NETosis Nets were first described in 2004 as a novel host defense mechanism to trap and kill foreign pathogens Recent evidence shows that NETs also participate in the pathogenesis of a variety of inflammatory and autoimmune diseases including SLE
The investigators recently highlighted this phenomenon in SSc especially in patients with vascular complications andor at a early stage of the disease The investigators will now explore the factors implicated in this dysregulation of NETosis in SSc
Neutrophils are potent producers of ROS and may play a role in endothelial cells and fibrobasts dysfunction as in autoantibodies generation However their role in SSC pathogenesis remains to be determined Recent studies discovered abnormal regulation of Neutrophil Extracellular Traps NETs in other auto-immune diseases such as Systemic Lupus Erythematosus SLE NETs are web-like structures composed of chromatin backbones and granular molecules They are released by activated neutrophils through a process called NETosis Nets were first described in 2004 as a novel host defense mechanism to trap and kill foreign pathogens Recent evidence shows that NETs also participate in the pathogenesis of a variety of inflammatory and autoimmune diseases including SLE
The investigators recently highlighted this phenomenon in SSc especially in patients with vascular complications andor at a early stage of the disease The investigators will now explore the factors implicated in this dysregulation of NETosis in SSc
Detailed Description:
This study is designed to assess the role of Neutrophil Extracellular Traps NETs in Systemic SClerosis SSC as well as to evaluate the correlation between NETs production and NETs composition and the different complications and phenotypes observed in SSC
100 SSC patients 30 other connective tissue disease patients and 130 healthy subjects will be recruited Blood samples will be collected to obtain plasma serum and polynuclear neutrophils by negative selection
100 SSC patients 30 other connective tissue disease patients and 130 healthy subjects will be recruited Blood samples will be collected to obtain plasma serum and polynuclear neutrophils by negative selection
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None