Ignite Creation Date:
2024-07-17 @ 10:58 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06484036
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-03
First Post:
2024-06-24
Brief Title:
Effectiveness of Periodontitis Treatment on the Metabolic Activity of Symptomatic Carotid Atherosclerotic Plaque Responsible for Ischemic Stroke
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Effectiveness of Periodontitis Treatment on the Metabolic Activity of Symptomatic Carotid Atherosclerotic Plaque Responsible for Ischemic Stroke a Multicenter Randomized Controlled Trial a Multicenter Randomized Controlled Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PerioStroke
Brief Summary:
Cardiovascular disease is the worlds leading cause of death Atherothrombosis is a common cause of ischemic stroke
A strong epidemiological link has been established between periodontitis and the risk of stroke It shares common risk factors with atherothrombosis and its severe form is associated with low-grade systemic inflammation and daily low-intensity bacteremia Atherothrombosis is a frequent cause of ischemic stroke
Periodontal bacteria have been found within atheromatous plaques correlated with a greater risk of rupture
Thus periodontitis could be a modifiable risk factor for atherothrombosis and future vascular events its early diagnosis and treatment could have a major impact on cardiovascular prevention
Hypothesis In patients with periodontitis who have had an ischemic stroke periodontal treatment may reduce atherosclerotic plaque activity
A strong epidemiological link has been established between periodontitis and the risk of stroke It shares common risk factors with atherothrombosis and its severe form is associated with low-grade systemic inflammation and daily low-intensity bacteremia Atherothrombosis is a frequent cause of ischemic stroke
Periodontal bacteria have been found within atheromatous plaques correlated with a greater risk of rupture
Thus periodontitis could be a modifiable risk factor for atherothrombosis and future vascular events its early diagnosis and treatment could have a major impact on cardiovascular prevention
Hypothesis In patients with periodontitis who have had an ischemic stroke periodontal treatment may reduce atherosclerotic plaque activity
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None