Ignite Creation Date:
2024-07-17 @ 11:01 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06499844
Status:
RECRUITING
Last Update Posted:
2024-07-15
First Post:
2024-06-26
Brief Title:
Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation
Sponsor:
University of Iowa
Organization:
University of Iowa
Study Overview
Official Title:
Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CAP NOVA
Brief Summary:
The increase in skin blood flow in response to rapid local heating of the skin ie cutaneous vasodilation is commonly used to assess nitric oxide NO-dependent dilation and overall microvascular function Historically rapid local heating to 42C was considered the standard approach for these assessments More recently many investigators have adopted rapid local to 39C instead based on its larger dependency on NO and therefore improved ability to quantify NO-dependent dilation without the use of pharmacological techniques However to date only one direct methodological comparison between these protocols has been performed
In this study the investigators use the blood vessels in the skin as a representative vascular bed for examining mechanisms of microvascular dysfunction in humans Using a minimally invasive technique intradermal microdialysis for the local delivery of pharmaceutical agents they examine the blood vessels in a nickel-sized area of the skin in young adults ages 18 - 30 years old Local heating of the skin at the microdialysis sites is used to explore differences in mechanisms governing microvascular control As a compliment to these measurements the investigators also have participants fill out a variety of surveys to assess things such as sleep quality physical activity daily stressors etc
In this study the investigators use the blood vessels in the skin as a representative vascular bed for examining mechanisms of microvascular dysfunction in humans Using a minimally invasive technique intradermal microdialysis for the local delivery of pharmaceutical agents they examine the blood vessels in a nickel-sized area of the skin in young adults ages 18 - 30 years old Local heating of the skin at the microdialysis sites is used to explore differences in mechanisms governing microvascular control As a compliment to these measurements the investigators also have participants fill out a variety of surveys to assess things such as sleep quality physical activity daily stressors etc
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None