Ignite Creation Date:
2024-07-17 @ 11:06 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06485817
Status:
COMPLETED
Last Update Posted:
2024-07-05
First Post:
2024-06-07
Brief Title:
How Stress Alters Opioid Drug Effects
Sponsor:
University of Oslo
Organization:
University of Oslo
Study Overview
Official Title:
How Distress Alters Opioid Drug Effects and Abuse Liability
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
OPIOIDREWARD
Brief Summary:
The main objective of the study is to test the hypothesis that opioid drug effects vary as a function of pre-drug affective state Specifically it is hypothesized that social stress induction enhances opioid drug wanting compared a non-stress control condition
Detailed Description:
Healthy participants complete four experiment sessions in a placebo-controlled double-blind randomized repeated-measures psychopharmacological study Participants completed four combinations of pre-drug state induction social stress or no-stress and drug intravenous oxycodone or saline
Temporary and reversible social stress is induced using the Repeatable Social Stress Test ReSST which enables repeated administrations of stress-inductions Across four sessions participants experience two carefully tailored tasks to provoke the experience of social evaluative threat and two non-stressful control tasks
After each state inductions participants receive an injection of opioid drug or saline After a drug absorption phase and viewing of a state reinstatement video designed to evoke a mild form of social evaluative threat participants perform a drug-self-administration test to determine the potency of a second dose
Self-reported affect mental and physiological state and drug effects are assessed throughout the session
Temporary and reversible social stress is induced using the Repeatable Social Stress Test ReSST which enables repeated administrations of stress-inductions Across four sessions participants experience two carefully tailored tasks to provoke the experience of social evaluative threat and two non-stressful control tasks
After each state inductions participants receive an injection of opioid drug or saline After a drug absorption phase and viewing of a state reinstatement video designed to evoke a mild form of social evaluative threat participants perform a drug-self-administration test to determine the potency of a second dose
Self-reported affect mental and physiological state and drug effects are assessed throughout the session
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| httpsosfiobcxv8 | OTHER | None | None |