Ignite Creation Date:
2024-07-17 @ 11:09 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06490770
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-08
First Post:
2024-06-13
Brief Title:
Analysis of the Pathophysiological and Functional State of the Knee Joint
Sponsor:
Istituto Ortopedico Rizzoli
Organization:
Istituto Ortopedico Rizzoli
Study Overview
Official Title:
Analysis of the Pathophysiological and Functional State of the Knee Joint
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Gait-MRI-Knee
Brief Summary:
Osteoarthritis is the most common degenerative condition affecting the knee joint globally with an incidence of about 7 of the population In Italy it affects approximately 39 million people with a direct treatment cost of around 25 billion At the joint level osteoarthritis manifests with pain and reduced functionality worsening as the disease progresses and severely limiting knee movement Compounding this osteoarthritis can impact both elderly and younger individuals due to traumatic factors
Despite its significant impact effective treatments for osteoarthritis that address its underlying causes are still lacking focusing mainly on symptom management Therefore improving diagnostic and prognostic approaches is crucial to better understand its onset and progression
MRI is a primary diagnostic tool for assessing the knee joints pathophysiological state It uses tissue-specific sequences to investigate joint homeostasis in detail although it primarily provides insights into morphology structure and tissue composition rather than functional changes within the joint This limitation is noteworthy because joint homeostasis involves complex interactions among biomechanical structural and biological processes which are directly influenced by osteoarthritis
Gait analysis provides valuable diagnostic information on joint function By integrating sensor measurements and electronic systems with patient-specific musculoskeletal models derived from MRI morphometric data it is possible to assess the forces and moments within the joint during specific movements
Given that osteoarthritis affects the entire joint employing multidisciplinary approaches can enhance diagnostic precision and provide insights into the progressive impact of degenerative conditions like osteoarthritis on joint health
Despite its significant impact effective treatments for osteoarthritis that address its underlying causes are still lacking focusing mainly on symptom management Therefore improving diagnostic and prognostic approaches is crucial to better understand its onset and progression
MRI is a primary diagnostic tool for assessing the knee joints pathophysiological state It uses tissue-specific sequences to investigate joint homeostasis in detail although it primarily provides insights into morphology structure and tissue composition rather than functional changes within the joint This limitation is noteworthy because joint homeostasis involves complex interactions among biomechanical structural and biological processes which are directly influenced by osteoarthritis
Gait analysis provides valuable diagnostic information on joint function By integrating sensor measurements and electronic systems with patient-specific musculoskeletal models derived from MRI morphometric data it is possible to assess the forces and moments within the joint during specific movements
Given that osteoarthritis affects the entire joint employing multidisciplinary approaches can enhance diagnostic precision and provide insights into the progressive impact of degenerative conditions like osteoarthritis on joint health
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None