Ignite Creation Date:
2024-07-17 @ 11:11 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06491264
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-09
First Post:
2024-04-17
Brief Title:
Multiparameter Optimized tES for Memory in Aging
Sponsor:
Medical University of South Carolina
Organization:
Medical University of South Carolina
Study Overview
Official Title:
Concurrent Multiparameter Optimized Noninvasive Brain Stimulation for Working Memory in Aging
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
With an aging population worldwide it is critical to develop effective interventions promoting healthy cognitive aging Transcranial electrical stimulation tES is a promising but not fully realized noninvasive brain stimulation approach that could improve memory This study investigates the behavioral and electrocortical effects of personalized tES in aging to determine whether whether optimal dosing electrode placements and waveforms elicit stronger responses
Detailed Description:
With an aging population worldwide it is critical to develop effective interventions promoting healthy cognitive aging A key component of healthy cognition is intact working memory an executive neural process holding information temporarily With increasing age working memory capacity decreases and is associated with a loss of independence thus incentivizing the need to retain a healthy working memory capacity In addition to facilitating healthy aging developing a method that improves working memory could help those diagnosed with mild cognitive impairment MCI and Alzheimers Disease AD which is currently is the 6th leading cause of death in the US and has an annual economic burden of 305 billion
A potential approach to improve working memory is transcranial electrical stimulation tES a noninvasive brain stimulation method using scalp electrodes to deliver low electrical currents of 2 milliamps mA over the cortical target While some prior studies have shown that prefrontal tES can improve working memory in older adults there are small meta-analytic effect sizes and no FDA-approved indications to date These mixed results could be due to applying one-size-fits-all and suboptimal tES parameters In this study the investigators will test the effects of personalized parameters including dosing electrode positioning and waveforms compared to standard tES and placebo
A potential approach to improve working memory is transcranial electrical stimulation tES a noninvasive brain stimulation method using scalp electrodes to deliver low electrical currents of 2 milliamps mA over the cortical target While some prior studies have shown that prefrontal tES can improve working memory in older adults there are small meta-analytic effect sizes and no FDA-approved indications to date These mixed results could be due to applying one-size-fits-all and suboptimal tES parameters In this study the investigators will test the effects of personalized parameters including dosing electrode positioning and waveforms compared to standard tES and placebo
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
True
Is an FDA AA801 Violation?:
None