Ignite Creation Date:
2024-07-17 @ 11:14 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06484088
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-15
First Post:
2024-06-29
Brief Title:
Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Characterizing the Brain Circuitry and Neural Activity Mediating Frustration
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10-22
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background
Irritability can be defined as an unusually strong response to frustration these responses may include severe temper outbursts and a constant grumpy mood Irritability is a common symptom of many mental health disorders Little is known about how the brain responds to frustration and few treatments are available for this problem Researchers want to know more about how the brain responds to frustration
Objective
To learn how the brain responds to frustration
Eligibility
Healthy adults aged 18 to 55 years They must have been screened through studies 01-M-0254 or 17-M-0181
Design
Participants will have up to 3 study visits in 2 months Each visit will last up to 4 hours
Visit 1 Participants will be screened They will have a physical exam They will complete questionnaires about how often and how easily they get angry or grumpy They will be trained to use a device that measures hand grip
Visit 2 Participants will have a magnetic resonance imaging MRI scan They will lie on a table that slides into a tube Padding will hold their head still
Visit 3 Participants will undergo magnetoencephalography MEG A cone with detectors will be lowered over their head while they are seated The MEG will measure the magnetic fields in the participant s brain both while they are resting and while they are doing the frustration task For the task they will hold a grip device in each hand They will use the devices to pick 1 of 2 doors on a computer screen The task has 3 parts The participant s face will be filmed during this task
Irritability can be defined as an unusually strong response to frustration these responses may include severe temper outbursts and a constant grumpy mood Irritability is a common symptom of many mental health disorders Little is known about how the brain responds to frustration and few treatments are available for this problem Researchers want to know more about how the brain responds to frustration
Objective
To learn how the brain responds to frustration
Eligibility
Healthy adults aged 18 to 55 years They must have been screened through studies 01-M-0254 or 17-M-0181
Design
Participants will have up to 3 study visits in 2 months Each visit will last up to 4 hours
Visit 1 Participants will be screened They will have a physical exam They will complete questionnaires about how often and how easily they get angry or grumpy They will be trained to use a device that measures hand grip
Visit 2 Participants will have a magnetic resonance imaging MRI scan They will lie on a table that slides into a tube Padding will hold their head still
Visit 3 Participants will undergo magnetoencephalography MEG A cone with detectors will be lowered over their head while they are seated The MEG will measure the magnetic fields in the participant s brain both while they are resting and while they are doing the frustration task For the task they will hold a grip device in each hand They will use the devices to pick 1 of 2 doors on a computer screen The task has 3 parts The participant s face will be filmed during this task
Detailed Description:
STUDY DESCRIPTION
Participants in this study will be healthy adults This protocol uses a frustration induction task magnetoencephalography MEG and structural magnetic resonance imaging MRI coupled with physical and self-report assessment of frustration to study brain mechanisms underlying frustration in adults This study is part of a cross-species project hence hypotheses are based on neural mechanisms of frustration identified in mice
OBJECTIVES
To use a frustration induction task MEG and brain MRI coupled with physical and self-report assessment of frustration to measure how frustration alters synchronized neural activities Specifically we will identify brain circuits and neural oscillations that potentially underly the emotional and behavioral consequences of frustration
ENDPOINTS
1 The power of neural oscillations in the cortical-basal gangliathalamic circuit which we hypothesize will be altered by frustration comparing pre and post-frustration resting states and increased more by unexpected reward omission than reward attainment
2 Coherence of neural oscillations in the above-mentioned circuit which we hypothesize will be increased in the beta band by unexpected reward omission but not by expected reward omission and that this decrease will accumulate with the number of frustration episodes 3 Frustration rating by self-report facial expression and the duration and strength of gripping which we hypothesize will be higher after unexpected reward omission than after expected reward omission
Participants in this study will be healthy adults This protocol uses a frustration induction task magnetoencephalography MEG and structural magnetic resonance imaging MRI coupled with physical and self-report assessment of frustration to study brain mechanisms underlying frustration in adults This study is part of a cross-species project hence hypotheses are based on neural mechanisms of frustration identified in mice
OBJECTIVES
To use a frustration induction task MEG and brain MRI coupled with physical and self-report assessment of frustration to measure how frustration alters synchronized neural activities Specifically we will identify brain circuits and neural oscillations that potentially underly the emotional and behavioral consequences of frustration
ENDPOINTS
1 The power of neural oscillations in the cortical-basal gangliathalamic circuit which we hypothesize will be altered by frustration comparing pre and post-frustration resting states and increased more by unexpected reward omission than reward attainment
2 Coherence of neural oscillations in the above-mentioned circuit which we hypothesize will be increased in the beta band by unexpected reward omission but not by expected reward omission and that this decrease will accumulate with the number of frustration episodes 3 Frustration rating by self-report facial expression and the duration and strength of gripping which we hypothesize will be higher after unexpected reward omission than after expected reward omission
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 002073-M | None | None | None |