Ignite Creation Date:
2024-07-17 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06468748
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-21
First Post:
2024-06-05
Brief Title:
The Effects of Semaglutide on Body Composition and Performance in Military Personnel
Sponsor:
United States Army Research Institute of Environmental Medicine
Organization:
United States Army Research Institute of Environmental Medicine
Study Overview
Official Title:
The Effects of a GLP-1R Agonist the Drug Wegovy on Body Composition and Performance in Military Personnel
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The obesity epidemic presents a growing concern in the United States affecting more than 42 of adults This epidemic extends its impact to chronic diseases and escalating healthcare expenses Its reach has even influenced the military with more than 20 of Soldiers being classified as obese based on Body Mass Index 30 kgm2 Current preventative and countermeasures have produced limited success prompting consideration of pharmacotherapy Within this context glucagon-like peptide-1 receptor agonists GLP-1RAs such as semaglutide have emerged as a promising treatment for obesity Semaglutide can induce significant weight loss primarily through fat reduction However questions persist regarding its effects on lean mass physical performance bone structure and how it influences the underlying metabolic and hormonal milieu Furthermore no studies have been completed in military personnel who must exercise regularly Therefore the investigators will conduct a single-center open-label observational trial The trial will consist of a 24-week semaglutide treatment period and a non-treated 52-week follow-up period We will test the feasibility and potential benefits of semaglutide in military populations with a focus on understanding how semaglutide influences body composition physical performance hormones and metabolism This research holds military significance as obesity rates among service members continue to rise undermining their medical readiness Ultimately it is important to understand if GLP-1RAs can provide a viable solution to obesity in military personnel and if there might be an unexpected effect on physical readiness due to the nature of the weight loss This could cut down on healthcare expenses by reducing the reliance on weight-related initiatives and consequently lowering military separations
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None