Ignite Creation Date:
2024-07-17 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06482853
Status:
RECRUITING
Last Update Posted:
2024-07-01
First Post:
2024-06-26
Brief Title:
Cardiovascular Effects of Angiotensin-1-7 in Obesity Hypertension
Sponsor:
Milton S Hershey Medical Center
Organization:
Milton S Hershey Medical Center
Study Overview
Official Title:
Cardiovascular Effects of Angiotensin-1-7 in Obesity Hypertension
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Obesity is a global health concern that is associated with high blood pressure and an increased risk for developing cardiovascular disease The purpose of this study is to find out if the investigational drug angiotensin-1-7 can improve cardiovascular health in people with obesity and high blood pressure
Detailed Description:
A randomized double blind placebo controlled crossover study will be conducted to determine if acute intravenous angiotensin-1-7 infusion reduces cardiovascular sympathetic tone and blood pressure and improves the function of blood vessels in participants with obesity hypertension This is an outpatient study that requires a screening visit and if eligible two study visits separated by at least one week in the Clinical Research Center within the Penn State Milton S Hershey Medical Center The study visits will include intravenous infusion of angiotensin-1-7 or saline for approximately two hours starting with increasing doses and holding at a steady-state dose Endothelial function will be measured and blood samples collected at baseline and at the end of infusion Blood pressure heart rate and muscle sympathetic nerve activity via microneurography will be measured continuously throughout the study Each study visit will last approximately 4 hours
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL170140 | NIH | None | None |