Ignite Creation Date:
2024-07-17 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06491394
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-09
First Post:
2024-07-01
Brief Title:
Lactoferrin Effect on Kidney and Heart of Rhabdomyolysis Rats
Sponsor:
Aswan University Hospital
Organization:
Aswan University Hospital
Study Overview
Official Title:
Effect of Lactoferrin Administration on Rhabdomyolysis-induced Heart and Kidney Injury in Rats
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study focuses on detecting the possible beneficial effect of Lactoferrin Lf administration on the kidney and the heart of glycerol-induced rhabdomyolysis RM in rats and its relation to ferroptosis and AMPKNrf2 HO-1 signalling pathway The main questions it aims to answer are
1 Is Lf administration 30 min before or after RM induction in rats beneficial to kidneys and heart
2 When administered to glycerol-induced rats does Lf act by upregulating the AMPKNrf2 HO-1 signalling pathway and inhibiting ferroptosis
1 Is Lf administration 30 min before or after RM induction in rats beneficial to kidneys and heart
2 When administered to glycerol-induced rats does Lf act by upregulating the AMPKNrf2 HO-1 signalling pathway and inhibiting ferroptosis
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None