Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001258
Status:
COMPLETED
Last Update Posted:
2024-05-28
First Post:
1999-11-03
Brief Title:
Studies of Frontal Lobe Brain Functioning in Schizophrenia
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Studies of Frontal Lobe Function During Cognitive Stimulation as Measured With Oxygen-15 Water Positron Emission Tomography in Normal Subjects and Patients With Neuropsychiatric Disorders
Status:
COMPLETED
Status Verified Date:
2024-01-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to use brain imaging technology to investigate the role of the frontal lobe of the brain in the thinking of individuals with schizophrenia and other neuropsychiatric disorders and healthy volunteers
Participants in this study will undergo a positron emission tomography PET scan of the brain while performing neuropsychological tests Some of the tests involve cognitive operations that depend upon the frontal cortex Interactions between frontal lobe activation cognitive behavior and neuropharmacology will be assessed by measuring regional cerebral blood flow rCBF during treatment with drugs that may affect frontal lobe physiology
Participants in this study will undergo a positron emission tomography PET scan of the brain while performing neuropsychological tests Some of the tests involve cognitive operations that depend upon the frontal cortex Interactions between frontal lobe activation cognitive behavior and neuropharmacology will be assessed by measuring regional cerebral blood flow rCBF during treatment with drugs that may affect frontal lobe physiology
Detailed Description:
The purpose of this work is to investigate the role of the frontal lobe and its connections for cognition in health and in neuropsychiatric diseases particularly schizophrenia Regional cerebral blood flow rCBF will be measured with oxygen-15 water positron emission tomography PET while subjects are either at rest or are performing a variety of neuropsychological tests Some of these tests involve cognitive operations that are posited to depend upon the frontal cortex such as the use of working memory for abstract reasoning and problem solving formation and maintenance of conceptual sets set shifting sequencing and delayed response others control for nonspecific sensory and motor aspects of these measurements or are contrast conditions posited to depend on other brain regions Interactions between regional activation cognitive behavior and neuropharmacology will be assessed by measuring cognitively-related rCBF during treatment with drugs that may affect frontal lobe physiology Hypotheses about the genetic determinants of these relationships will also be tested by comparing rCBF measures across individuals harboring different genotypes detemined through protocol 95-M-0150
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 90-M-0014 | None | None | None |