Ignite Creation Date:
2024-07-17 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06486805
Status:
RECRUITING
Last Update Posted:
2024-07-05
First Post:
2024-06-21
Brief Title:
N-Acetyl Cysteine Effect on Liver Function After Mitral Valve Replacement
Sponsor:
Kasr El Aini Hospital
Organization:
Kasr El Aini Hospital
Study Overview
Official Title:
The Effect of N-Acetylcysteine on Liver Functions After Mitral Valve Replacement A Randomized Controlled Trial
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NAC
Brief Summary:
This study aimed at the impact of the N-acetyl cysteine on the improvement of liver function subsequently on-pum mitral valve replacement Following a clinical trial design 34 candidates of on-pump MVR aged 30 to 70 years with normal liver and renal function were selected The candidates were randomly divided into intervention IV150 mg kg N-acetyl cysteine over 15 min and control groups normal saline as placebo n 17 in each group
Detailed Description:
In a randomized controlled prospective study in a teaching hospital after approval of the ethical committee and informed consent 34 candidates of on-pump MVR aged 30 to 70 years with normal liver and renal function were selected The candidates were randomly divided into intervention IV150 mg kg N-acetyl cysteine over 15 min then 50 mgkg over 4 hrs and control groups normal saline as placebo n 17 in each groupand we will assess the effect of NAC on intra-operative hemodynamics and post-operative its protective rule against oxidative stress and liver dysfunction
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None