Viewing Study NCT06500663



Ignite Creation Date: 2024-07-17 @ 11:27 AM
Last Modification Date: 2024-10-26 @ 3:34 PM
Study NCT ID: NCT06500663
Status: NOT_YET_RECRUITING
Last Update Posted: 2024-07-15
First Post: 2024-07-08

Brief Title: Studying Thyroid Function of Haemodialysis Patients in Upper Egypt Two Centers Study
Sponsor: Sahar Ezeldeen Hussein Ali
Organization: Assiut University

Study Overview

Official Title: Studying Thyroid Function of Haemodialysis Patients in Upper Egypt Two Centers Study
Status: NOT_YET_RECRUITING
Status Verified Date: 2024-07
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: 1 The study aims to investigate the prevalence of thyroid dysfunction in haemodialysis patients and study the association of thyroid hormone concentration with health status of those patients
2 Study the effects of frequent haemodialysis on thyroid function
Detailed Description: 21 Background Research Question Available Data from the literature Current strategy for dealing with the problem Rationale of the research that paves the way to the aims of the work 200-250 words max The study of thyroid function in hemodialysis patients is a critical area of research due to the complex interplay between renal failure and thyroid pathology Chronic kidney disease CKD and end-stage renal disease ESRD have been associated with various thyroid abnormalities including hypothyroidism and low triiodothyronine T3 syndrome 1 These conditions can significantly impact the morbidity and mortality of patients undergoing hemodialysis 2

In hemodialysis patients the prevalence of thyroid dysfunction is higher compared to the general population3 This is partly due to the altered metabolism and clearance of thyroid hormones and the impact of uremic toxins on thyroid function 4 Moreover thyroid hormones play a crucial role in cardiovascular health which is of particular concern in hemodialysis patients who are already at an increased risk for cardiovascular events 5

Recent studies have shown that even subclinical hypothyroidism where patients have an elevated thyroid-stimulating hormone TSH level but normal thyroxine T4 levels can be associated with adverse outcomes in hemodialysis patients 6 This condition may contribute to an increased risk of cardiovascular disease and mortality 7

The assessment of thyroid function in hemodialysis patients typically involves measuring serum levels of TSH free T4 and T3 8 However interpreting these levels can be challenging due to the effects of medications nutritional status and non-thyroidal illness on the thyroid axis 9 It is also important to consider the impact of hemodilution on thyroid function tests as it can lead to misinterpretation of the results 10

Management of thyroid dysfunction in hemodialysis patients requires careful consideration While thyroid hormone replacement therapy is commonly used to treat hypothyroidism the optimal target levels of TSH and T4 in this population are still under investigation 11 Additionally the benefits of treating subclinical hypothyroidism in hemodialysis patients remain uncertain 12

In the context of Egypt the prevalence of thyroid dysfunction among hemodialysis patients mirrors global trends A study conducted in a South Indian cohort which may have parallels in Egypt due to similar dietary and environmental factors found a high prevalence of subclinical hypothyroidism in hemodialysis patients13 This suggests that thyroid screening and management should be an integral part of care for hemodialysis patients in Egypt as well

Egypts healthcare system has been making strides in improving the management of chronic diseases including CKD and its complications With a growing focus on preventive care and early intervention the management of thyroid dysfunction in hemodialysis patients is likely to receive more attention in the coming years 14

In Upper Egypt research has been conducted to investigate the prevalence and nature of thyroid abnormalities among hemodialysis patients A cross-sectional observational report enrolled 160 subjects at Al-Hussein Hospital Al-Azhar University and the National Institute of Nephrology and Urology revealing significant correlations between thyroid hormones and various clinical parameters 15 Another study assessed thyroid hormone levels in 200 patients with chronic renal failure undergoing maintenance hemodialysis finding a high prevalence of thyroid hormone dysfunction even in clinically euthyroid patients16

In conclusion the study of thyroid function in hemodialysis patients is essential for optimizing patient outcomes With ongoing research and improved clinical practices the management of thyroid dysfunction in this vulnerable population can be enhanced As Egypt continues to develop its healthcare infrastructure it is poised to make significant contributions to this field of study 17

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: False
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None
Secondary IDs
Secondary ID Type Domain Link
faculty OTHER None None