Ignite Creation Date:
2024-07-17 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06465134
Status:
RECRUITING
Last Update Posted:
2024-06-18
First Post:
2024-03-26
Brief Title:
Mechanisms for Atrial Fibrillation in Obstructive Sleep Apnea
Sponsor:
Danderyd Hospital
Organization:
Danderyd Hospital
Study Overview
Official Title:
Mechanisms for Incident and Recurrent Atrial Fibrillation in Patients With Obstructive Sleep Apnea AF - Milano Trieste Stockholm
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AF-MiTriSto
Brief Summary:
Atrial fibrillation AF is the most common rhythm disorder and involves an increased risk of cardiovascular disease and death impaired quality of life and a high proportion of healthcare consumption An important risk factor is obstructive sleep apnea OSA However it is not fully understood why OSA induces AF It may be due to a proinflammatory state sympathetic activation and acute changes in blood pressure during apnéas but few studies are performed Hypertension with its coherent arterial stiffness is related to all these factors is common in OSA and is the most common cause of AF The cause of AF in hypertensive subjects is believed due to a pressure overloaded left heart with dilation and fibrosis of the left atrium promoting the development of AF Hypertension and arterial stiffness can thus be important triggering factors for AF in OSA
In this project teh investigators investigate the occurrence of OSA in AF patients Furthermore underlying mechanisms for the development and recurrence of AF after intervention in OSA patients are investigated
300 patients scheduled for AF ablation or cardioversion are invited and examined with sleep registration 24h blood pressure aortic stiffness measurement test of autonomic function echocardiography ECG and labs The patients are followed at months 3 6 and 12 with 7 days ECG for recurrence The aim is to give insights into the need for screening for OSA in patients with AF The study also aim at enabling preventive treatment through better understanding of underlying treatable mechanisms The results are believed to lead to fewer new AFs as well as fewer AF recurrences in patients with OSA
In this project teh investigators investigate the occurrence of OSA in AF patients Furthermore underlying mechanisms for the development and recurrence of AF after intervention in OSA patients are investigated
300 patients scheduled for AF ablation or cardioversion are invited and examined with sleep registration 24h blood pressure aortic stiffness measurement test of autonomic function echocardiography ECG and labs The patients are followed at months 3 6 and 12 with 7 days ECG for recurrence The aim is to give insights into the need for screening for OSA in patients with AF The study also aim at enabling preventive treatment through better understanding of underlying treatable mechanisms The results are believed to lead to fewer new AFs as well as fewer AF recurrences in patients with OSA
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None