Ignite Creation Date:
2024-07-17 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06501547
Status:
RECRUITING
Last Update Posted:
2024-07-15
First Post:
2024-06-02
Brief Title:
Association of Leucocyte Telomere Length With DPAS Score in Skin Aging
Sponsor:
DrdrIrma Bernadette SpKK K
Organization:
Indonesia University
Study Overview
Official Title:
Association of Leucocyte Telomere Length With Clinical Examination and Dermoscopic Photoaging Scale DPAS Score in Skin Aging a Pilot Study
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal is to know the profile of photoaging based on clinical examination Dermoscopic Photoaging Scale and leucocyte telomere length
The main questions of Research are
what is the profile of photoaging based on clinical examination results in skin aging
what is the profile of photoaging based on DPAS Score in skin aging
what is the profile of leucocyte telomere length in skin aging
Participants are female and male with the age of 29-31 years old and 59-61 years old They will be examined by dermatovenereologist and will be photographed in 5 positions they will get dermocopy on forehead right cheek left cheek and chin and their blood will be drawn about 10 mL in order to get the profile of leucocyte telomere length
The main questions of Research are
what is the profile of photoaging based on clinical examination results in skin aging
what is the profile of photoaging based on DPAS Score in skin aging
what is the profile of leucocyte telomere length in skin aging
Participants are female and male with the age of 29-31 years old and 59-61 years old They will be examined by dermatovenereologist and will be photographed in 5 positions they will get dermocopy on forehead right cheek left cheek and chin and their blood will be drawn about 10 mL in order to get the profile of leucocyte telomere length
Detailed Description:
Skin aging is a process of deterioration in the physiological structure and function of the skin that significantly increases in the 4th and 5th decades of life Skin aging is a combination of physiological and pathological aging Physiological change cannot be avoided and mandatory for everyone pathological aging ir extrinsic aging is an abnormal skin condition caused by cigarettes pollution and ultraviolet UV In general the clinical characteristics of skin aging consist of pigmentation changes hydration disorders the appearance of wrinkles and skin tumors The photoaging assessment was first proposed in 1996 by Dr Richard Glogau The Glogau scale assesses photoaging based on clinical assessment grouped into 4 categories namely types I II III and IVwhere each type is graded by the severity of wrinkles namely from mild moderate advanced and severe Isik et al developed an instrument for quantitative skin aging assessment using dermoscopy This examination is non-invasive and is expected to provide a more objective assessment There are four facial regions assessed in the DPAS score calculation forehead right cheek left cheek and chin The sum of the scores of the four regions is assessed based on 11 parameters with a maximum final score of 44 Telomeres are repetitive DNA-Protein complexes located at the ends of chromosomes of eukarotic cells and their function is to maintain chromosome stability during cell division by protecting chromosomes from degradation and fusion Many factors affect telomere length such as body mass index hormonal therapy antioxidant intake chronic diseases and gender Research by son et al found that telomere length shortening was validated to increase the odds of skin aging OR096 95 CI 09332-099566 P 003 Telomeres are closely linked to cellular aging especially in dermal cells and telomere shortening in skin fibroblasts may lead to epidermal aging and barrier function defectcs
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None