Ignite Creation Date:
2024-07-17 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06502015
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-15
First Post:
2024-06-18
Brief Title:
Biomarkers in Autoimmune Disease of Nervous System
Sponsor:
Tongji Hospital
Organization:
Tongji Hospital
Study Overview
Official Title:
Biomarkers of Neurological Autoimmune Diseases
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Neurological autoimmune diseases are a group of disorders characterized by the abnormal immune response attacking the nervous system including the brain spinal cord and peripheral nerves These diseases exhibit high heterogeneity diverse clinical presentations and are challenging to diagnose and manage due to a lack of effective treatments In this study the investigators will recruit eight kinds of autoimmune diseases of nervous system including Neuromyelitis Optica Spectrum Disorder NMOSD Myasthenia Gravis MG Chronic Inflammatory Demyelinating Polyradiculoneuropathy CIDP idiopathic inflammatory myopathy IIM and multiple sclerosis MS autoimmune encephalitis AE Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease MOGAD Through this study the investigators aim to discover biomarkers with high sensitivity specificity and stability which can support early diagnosis disease monitoring and personalized treatment for neurological autoimmune diseases thereby improving the quality of life and prognosis for patients
Detailed Description:
Autoimmune diseases of the nervous system are a type of disease in which the human immune system mistakenly attacks its own nervous system causing damage to the structure and function of the nervous system Its main pathogenic mechanism is that autoimmune cells autoantibodies and other immune molecules directly or indirectly attack the nervous system Autoimmune diseases of the nervous system can affect the central nervous system peripheral nervous system and neuromuscular junction leading to pathological changes such as neuronal or axonal damage demyelination and destruction of neuromuscular junction Autoimmune diseases of the nervous system are relatively rare with a wide range of damage and complex and diverse clinical manifestations They have the characteristics of complexity of immune diseases and high mortality and disability of nervous system diseases At present the understanding of the disease is limited and some diseases are difficult to diagnose Globally it is a major cause of disability in young and middle-aged people and can cause huge social and economic burdens However due to the lack of a series of relatively reliable prognostic predictors it is impossible to carry out personalized immunotherapy to achieve the best therapeutic effect and serious adverse events may occur Proteomics metabolomics intestinal microorganisms and intestinal high-throughput targeted metabolomics exosomes miRNA sequencing single-cell transcriptome sequencing and other detection methods and lymphocyte subsets have been hot topics in the study of various diseases in recent years It has been found that abnormalities in the expression and function of certain genes proteins metabolites miRNAs intestinal flora and lymphocyte subsets are closely related to the occurrence and development of many diseases and the functional disability of patients and have a good suggestive effect on prognosis judgment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None