Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005165
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Charleston Heart Study - Predictors of Coronary Disease in Blacks
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine the role of isolated systolic hypertension and other predictors of all-cause and coronary heart disease mortality in elderly Blacks and whites of the Charleston Heart Study cohort of 1960 and to compare and pool those findings with the Evans County Heart Study findings in order to develop a logistic risk function for Blacks Also to identify predictors of physical functioning in older Blacks and whites and to prepare rosters of the off-spring of the Charleston cohort for future studies of geneticfamilial influences on cardiovascular disease
Detailed Description:
BACKGROUND
Coronary heart disease is the leading cause of death among United States Blacks where coronary heart disease mortality rates are among the highest in the world There has been a marked decline in coronary heart disease mortality among Blacks in the United States including South Carolina since 1968 for reasons not well explained although hypertension control probably has contributed to the decline In spite of this decline evidence emerged that fatal and non-fatal coronary heart disease rates in Blacks exceeds those of whites Charleston Heart Study data showed that coronary heart disease cumulative survival probabilities for Black men were lower than white men during the first 20 years of the 25 year observation period A secular trend manifested itself with relatively higher rates in Blacks but in any event there was evidence that coronary disease was a major threat to Blacks
The Charleston Heart Study was initiated in 1960 Randomly selected Black and white men and women 35 years of age and over were examined to obtain details concerning angina myocardial infarction hypertension smoking blood pressure height weight and serum cholesterol levels The total cohort was 2283 persons The last screening of the cohort was in 1974-1975 until the this study which started in 1984
Over one half the Blacks in the United States live in the South and the Charleston Heart Study offered the opportunity to study disease and disability status of elderly Blacks in an environment that included urban and rural residents
DESIGN NARRATIVE
In 1984-1985 a 25 year follow-up was conducted on the original Charleston Heart Study cohort The vital status of 98 percent of the 1960 cohort was ascertained Ninety-three percent of the survivors were revisited interviewed and measured for blood pressure weight and height The interaction of socioeconomic status type A behavior and John Henry behavior scores were tested All-cause and coronary heart disease mortality were determined
In 1987-1988 approximately 1300 survivors were recalled for measurements of functional and cognitive status using the Framingham Functional Disability Questionnaire so that comparisons of results from Charleston and Framingham could be made Measurements were made of blood pressure height weight and heart function by auscultation ECG and echocardiography Lipoproteins glucose and other biochemical parameters were assessed The biomedical and sociodemographic determinants of long-term survival in Black men and women were quantified and compared with those of whites The risk factor significance of Minnesota-coded ECG abnormalities in Blacks versus whites were identified and quantified Familial aggregation of risk factors and potential causes of obesity were assessed
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Coronary heart disease is the leading cause of death among United States Blacks where coronary heart disease mortality rates are among the highest in the world There has been a marked decline in coronary heart disease mortality among Blacks in the United States including South Carolina since 1968 for reasons not well explained although hypertension control probably has contributed to the decline In spite of this decline evidence emerged that fatal and non-fatal coronary heart disease rates in Blacks exceeds those of whites Charleston Heart Study data showed that coronary heart disease cumulative survival probabilities for Black men were lower than white men during the first 20 years of the 25 year observation period A secular trend manifested itself with relatively higher rates in Blacks but in any event there was evidence that coronary disease was a major threat to Blacks
The Charleston Heart Study was initiated in 1960 Randomly selected Black and white men and women 35 years of age and over were examined to obtain details concerning angina myocardial infarction hypertension smoking blood pressure height weight and serum cholesterol levels The total cohort was 2283 persons The last screening of the cohort was in 1974-1975 until the this study which started in 1984
Over one half the Blacks in the United States live in the South and the Charleston Heart Study offered the opportunity to study disease and disability status of elderly Blacks in an environment that included urban and rural residents
DESIGN NARRATIVE
In 1984-1985 a 25 year follow-up was conducted on the original Charleston Heart Study cohort The vital status of 98 percent of the 1960 cohort was ascertained Ninety-three percent of the survivors were revisited interviewed and measured for blood pressure weight and height The interaction of socioeconomic status type A behavior and John Henry behavior scores were tested All-cause and coronary heart disease mortality were determined
In 1987-1988 approximately 1300 survivors were recalled for measurements of functional and cognitive status using the Framingham Functional Disability Questionnaire so that comparisons of results from Charleston and Framingham could be made Measurements were made of blood pressure height weight and heart function by auscultation ECG and echocardiography Lipoproteins glucose and other biochemical parameters were assessed The biomedical and sociodemographic determinants of long-term survival in Black men and women were quantified and compared with those of whites The risk factor significance of Minnesota-coded ECG abnormalities in Blacks versus whites were identified and quantified Familial aggregation of risk factors and potential causes of obesity were assessed
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL031397 | NIH | None | httpsreporternihgovquickSearchR01HL031397 |