Ignite Creation Date:
2024-07-17 @ 11:37 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06483061
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-01
First Post:
2024-06-25
Brief Title:
Enhanced MRI Imaging in Healthy Participants and Participants With Epilepsy
Sponsor:
University of Alberta
Organization:
University of Alberta
Study Overview
Official Title:
Ferumoxytol Enhanced Hippocampal Vascular Imaging in Epilepsy
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Temporal lobe epilepsy TLE is a common type of epilepsy and one of the most likely to not be controlled by medication For patients who do not respond to medication surgery can result in a cure of seizures Given the fact that around 50 of patients who undergo surgery are seizure free at 10 years there is a need to improve the understanding of what factors best predict surgical outcomes in order to improve our ability to select candidates for surgery
The demonstration of abnormalities in the temporal lobe on MRI is one of the best predictors of seizure free surgical outcomes Recent studies suggest that changes in specific subregions of the hippocampus could be the strongest predictors of surgical success however the small size of these regions millimeters make them very difficult to study with standard clinical MRI
Recently new MRI methods have been developed at Wayne State University to image hippocampal blood vessels using ferumoxytol infusion Feraheme ferumoxytol is a drug that is approved in the United States for the treatment of iron deficiency anemia and is currently being studied as an MRI contrast agent in 8 active clinical trials in the United States as well as a Parkinsons Disease study in Canada
The demonstration of abnormalities in the temporal lobe on MRI is one of the best predictors of seizure free surgical outcomes Recent studies suggest that changes in specific subregions of the hippocampus could be the strongest predictors of surgical success however the small size of these regions millimeters make them very difficult to study with standard clinical MRI
Recently new MRI methods have been developed at Wayne State University to image hippocampal blood vessels using ferumoxytol infusion Feraheme ferumoxytol is a drug that is approved in the United States for the treatment of iron deficiency anemia and is currently being studied as an MRI contrast agent in 8 active clinical trials in the United States as well as a Parkinsons Disease study in Canada
Detailed Description:
Hippocampal sclerosis is the most common pathological finding in temporal lobe epilepsy
While CA1 and CA4 subregions are typically affected considerable variability in the involvement of the different subregions has been recognized between patients with specific hippocampal subfield pathology being demonstrated to predict surgical outcomes in medically refractory patients Developing novel imaging biomarkers for hippocampal subfield pathology that can be obtained in vivo has the potential to allow more accurate prediction of surgical outcomes prior to surgery
A major challenge in studying hippocampal subregions is the small size of the structures which are often smaller than the resolution of conventional MRI techniques Cerebral blood vessels can be visualized with MRI using a variety of methods some which do not require MRI contrast and others that do The advantage of non-contrast methods is that subjects do not require intravenous contrast injections while the disadvantage is that the non-contrast methods are not capable of visualizing smaller vessels
Recently high-resolution vascular imaging of the hippocampus using ferumoxytol as an MRI contrast agent has been reported by researchers at Wayne State University It is believed that this method would provide the detail required to address the hypothesis that the microvasculature of hippocampal subregions is disrupted in temporal lobe epilepsy
OBJECTIVES
The Specific Aims of this study are
Aim 1 Implement ferumoxytol enhanced MRI imaging of cerebral vasculature with similar quality as compared to work conducted at Wayne State University Aim 2 Compare hippocampal microvasculature density of hippocampal subregions between participants with TLE and hippocampal sclerosis and control subjects
HYPOTHESES
1 Successful acquisition of susceptibility weighted imaging SWI vascular imaging with similar quality as compared to work conducted at Wayne State University will be possible
2 Participants with temporal lobe epilepsy and hippocampal sclerosis will demonstrate reduced microvasculature in hippocampal subfields that will correlate with previously reported regional MRI changes
METHODS DATA ANALYSIS
AIM 1
10 control subjects will be scanned using the Wayne State University SWI acquisition protocol Participants will receive ferumoxytol diluted with normal saline administered by a Registered Nurse using an MRI compatible IV infusion pump Any adverse events during the infusion scan will be documented and compared to previous ferumoxytol MRI safety data Data quality will be assessed both qualitatively and quantitatively Maps of the hippocampal microvasculature will be obtained and reviewed in order to confirm that the quality of the maps is comparable to the Wayne State University data Fractional vessel density FVD of microvasculature major arteries and major veins will be obtained and comparisons will be made to ensure that the mean values and standard deviations are comparable
AIM 2
20 control subjects and 20 participants with temporal lobe epilepsy and hippocampal sclerosis will be studied Participants will receive ferumoxytol diluted with normal saline administered by a Registered Nurse using a MRI compatible IV infusion pump Any adverse events will be documented
Microvasculature density of hippocampal subregions will be evaluated based on the same image analysis approach as the Wayne State University Group
While CA1 and CA4 subregions are typically affected considerable variability in the involvement of the different subregions has been recognized between patients with specific hippocampal subfield pathology being demonstrated to predict surgical outcomes in medically refractory patients Developing novel imaging biomarkers for hippocampal subfield pathology that can be obtained in vivo has the potential to allow more accurate prediction of surgical outcomes prior to surgery
A major challenge in studying hippocampal subregions is the small size of the structures which are often smaller than the resolution of conventional MRI techniques Cerebral blood vessels can be visualized with MRI using a variety of methods some which do not require MRI contrast and others that do The advantage of non-contrast methods is that subjects do not require intravenous contrast injections while the disadvantage is that the non-contrast methods are not capable of visualizing smaller vessels
Recently high-resolution vascular imaging of the hippocampus using ferumoxytol as an MRI contrast agent has been reported by researchers at Wayne State University It is believed that this method would provide the detail required to address the hypothesis that the microvasculature of hippocampal subregions is disrupted in temporal lobe epilepsy
OBJECTIVES
The Specific Aims of this study are
Aim 1 Implement ferumoxytol enhanced MRI imaging of cerebral vasculature with similar quality as compared to work conducted at Wayne State University Aim 2 Compare hippocampal microvasculature density of hippocampal subregions between participants with TLE and hippocampal sclerosis and control subjects
HYPOTHESES
1 Successful acquisition of susceptibility weighted imaging SWI vascular imaging with similar quality as compared to work conducted at Wayne State University will be possible
2 Participants with temporal lobe epilepsy and hippocampal sclerosis will demonstrate reduced microvasculature in hippocampal subfields that will correlate with previously reported regional MRI changes
METHODS DATA ANALYSIS
AIM 1
10 control subjects will be scanned using the Wayne State University SWI acquisition protocol Participants will receive ferumoxytol diluted with normal saline administered by a Registered Nurse using an MRI compatible IV infusion pump Any adverse events during the infusion scan will be documented and compared to previous ferumoxytol MRI safety data Data quality will be assessed both qualitatively and quantitatively Maps of the hippocampal microvasculature will be obtained and reviewed in order to confirm that the quality of the maps is comparable to the Wayne State University data Fractional vessel density FVD of microvasculature major arteries and major veins will be obtained and comparisons will be made to ensure that the mean values and standard deviations are comparable
AIM 2
20 control subjects and 20 participants with temporal lobe epilepsy and hippocampal sclerosis will be studied Participants will receive ferumoxytol diluted with normal saline administered by a Registered Nurse using a MRI compatible IV infusion pump Any adverse events will be documented
Microvasculature density of hippocampal subregions will be evaluated based on the same image analysis approach as the Wayne State University Group
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
True
Is an FDA AA801 Violation?:
None