Ignite Creation Date:
2024-07-17 @ 11:38 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06480071
Status:
COMPLETED
Last Update Posted:
2024-07-01
First Post:
2024-06-24
Brief Title:
The Role of Nasal Breathing for Perfomance in Elite Athletes
Sponsor:
Sahlgrenska University Hospital Sweden
Organization:
Sahlgrenska University Hospital Sweden
Study Overview
Official Title:
The Role of Nasal Breathing for Perfomance in Elite Athletes
Status:
COMPLETED
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study investigates the contribution of nasal breathing to the performance during aerobic and anaerobic heavy exercise in 12 male elite cyclists In a ramp test on a mechanically braked cycle ergometer Monark LT2 Varberg Sweden VO2 max heart rate respiratory frequency intranasal geometry and nasal airflow resitance as well as blood lactate and glucose was measured at each step of the ramp test and after a maximum exhaust test Nasal breathing was randomized to three sepratae tests normal open nose decongested nose with oxymetazoline 05mgml 2 sprays each nostril and with a nose clip The study showed that in the test with the nose clip mean blood lactate was significantly lower
Detailed Description:
Exercise experiments will be performed on12 elite male cycliststriathletes 20-40 years of age The subjects should have a VO2max of 65 mlminkg The subjects will perform pre-tests determining VO2max according to standard techniques Subjects will be recruited through local contacts at clubs for cyclists and triathletes Subjects should not have any medication no nasal symptomsdisease and no asthma and be non-smokers Subjects will be included after informed consent All subjects answer a respiratory and training questionnaire In total all participants will undergo four visits to the exercise lab CHP the first visit for characterisation pre-test and the following three visits will be the exercise trials in a randomized order All visits will take approximately 2 hours
Experimental trials Diet and Activity Before Testing Participants will be instructed to refrain from alcohol and asked not to perform vigorous exercise on the day before each experimental trial to record their diet on the first of these days and to repeat this diet on days before subsequent trials
Test day procedures Following an overnight fast participants will be instructed to consume 500 ml plain water upon wakening Upon arrival at the laboratory CHP height and nude body mass will be recorded and a blood sample hB and a urine sample will be collected A pre-trial urine specific gravity USG 1025 Atago Tokyo Japan will be considered as a euhydrated state Body composition will be assessed at the first experimental trial by dual-energy X-ray absorptiometry iDXA GE Medical Systems Madison WI USA Total fat and lean mass will be analyzed using enCore software version 1610
Visual analogue scale for nasal symptoms will be recorded The nose will be examined with anterior rhinometry and with a nasal endoscope Spirometry will be performed Intranasal geometry and nasal airway resistance will be measured immediately before during and after the exercise test
Following the anthropometric measurements an incremental maximal laboratory test will be performed on a mechanically braked cycle ergometer Monark LT2 Varberg Sweden adapted with a racing saddle drop handlebars and clip-in pedals Initial workload will be set at 110 W and increased by 35 W every 6 min with 2-min recovery intervalsdata collection points between workloads With assistance of a metronome pedal rate will be kept constant at 75 rpm through the entire test Testing will be continued until the participant no longer can maintain the required pedal rate Heart rate HR will be recorded every 5 s throughout the test Polar Electro OY model S10i Finland Blood samples Figure will be obtained to determine blood lactate concentration Lac and glucose immediately after each completed workload Lac values attained during the last workload will be considered to be maximal Maximal power output Wmax will be determined as the highest workload the participant can maintain for a complete 6-min period Environmental conditions during the experimental trials will be approximately 20C and 40-50 relative humidity
The exercise intensity corresponding to the onset of blood lactate accumulation OBLA will be identified on the Lac-power output curve by straight-line interpolation between the two closest points as the power output eliciting a Lac of 4 mmoll Power output and HR values at OBLA WOBLA and HROBLA respectively will be determined by straight-line interpolation
Outcomes VO2 CO2 HR ventilation rate ventilatory equivalents for oxygen and CO2 VeqO2
-1 and VeqCO2-1 RPE time to exhaustion Aerobic and anaerobic threshold
Experimental trials Diet and Activity Before Testing Participants will be instructed to refrain from alcohol and asked not to perform vigorous exercise on the day before each experimental trial to record their diet on the first of these days and to repeat this diet on days before subsequent trials
Test day procedures Following an overnight fast participants will be instructed to consume 500 ml plain water upon wakening Upon arrival at the laboratory CHP height and nude body mass will be recorded and a blood sample hB and a urine sample will be collected A pre-trial urine specific gravity USG 1025 Atago Tokyo Japan will be considered as a euhydrated state Body composition will be assessed at the first experimental trial by dual-energy X-ray absorptiometry iDXA GE Medical Systems Madison WI USA Total fat and lean mass will be analyzed using enCore software version 1610
Visual analogue scale for nasal symptoms will be recorded The nose will be examined with anterior rhinometry and with a nasal endoscope Spirometry will be performed Intranasal geometry and nasal airway resistance will be measured immediately before during and after the exercise test
Following the anthropometric measurements an incremental maximal laboratory test will be performed on a mechanically braked cycle ergometer Monark LT2 Varberg Sweden adapted with a racing saddle drop handlebars and clip-in pedals Initial workload will be set at 110 W and increased by 35 W every 6 min with 2-min recovery intervalsdata collection points between workloads With assistance of a metronome pedal rate will be kept constant at 75 rpm through the entire test Testing will be continued until the participant no longer can maintain the required pedal rate Heart rate HR will be recorded every 5 s throughout the test Polar Electro OY model S10i Finland Blood samples Figure will be obtained to determine blood lactate concentration Lac and glucose immediately after each completed workload Lac values attained during the last workload will be considered to be maximal Maximal power output Wmax will be determined as the highest workload the participant can maintain for a complete 6-min period Environmental conditions during the experimental trials will be approximately 20C and 40-50 relative humidity
The exercise intensity corresponding to the onset of blood lactate accumulation OBLA will be identified on the Lac-power output curve by straight-line interpolation between the two closest points as the power output eliciting a Lac of 4 mmoll Power output and HR values at OBLA WOBLA and HROBLA respectively will be determined by straight-line interpolation
Outcomes VO2 CO2 HR ventilation rate ventilatory equivalents for oxygen and CO2 VeqO2
-1 and VeqCO2-1 RPE time to exhaustion Aerobic and anaerobic threshold
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None