Ignite Creation Date:
2024-07-17 @ 11:40 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06492538
Status:
RECRUITING
Last Update Posted:
2024-07-09
First Post:
2024-07-01
Brief Title:
Biometric Changes After Intervention of Anterior Chamber Angle an Observational Study
Sponsor:
Zhongshan Ophthalmic Center Sun Yat-sen University
Organization:
Zhongshan Ophthalmic Center Sun Yat-sen University
Study Overview
Official Title:
Biometric Changes After Intervention of Anterior Chamber Angle an Observational Study
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The drainage angle in the anterior chamber of the eye mediates the outflow of aqueous humor and pathological changes here can lead to high intraocular pressure and glaucoma Minimally invasive glaucoma surgery particularly angle surgery has advanced recently allowing clear visualization of angle structures like the trabecular meshwork and Schlemms canal using surgical goniolens Techniques for angle intervention include widening the angle reopening closed angles and rebuilding outflow pathways using methods such as laser peripheral iridotomy Argon laser peripheral iridoplasty and mechanical separation of adhered tissues Our research team plans to conduct imaging studies to track the healing of angle tissues post-surgery aiming to support innovation and standardization of minimally invasive angle surgery
Detailed Description:
Pathological elevated intraocular pressure is one of the most important disease characteristics of glaucoma Blockage of aqueous humor outflow within the eye is the primary cause of high intraocular pressure The drainage angle in the anterior chamber of the eye mediates the outflow of aqueous humor Pathological changes in this area can lead to the development of high intraocular pressure and glaucoma such as primary angle closure glaucoma PACG caused by angle closure Minimally invasive glaucoma surgery has rapidly developed in recent years with angle surgery being a major branch With the use of surgical goniolens structures within the angle such as trabecular meshwork and Schlemms canal can be visualized clearly during surgery Methods for angle intervention include but not limit ed to widening the peripheral anterior chamber angle reopening adhered or appositionally closed angles and rebuilt outflow pathways by incising diseased areas to increase aqueous humor outflow Techniques include laser peripheral iridotomy LPI to relieve pupillary block and deepen the peripheral anterior chamber Argon laser peripheral iridoplasty ALPIP to stimulate iris contraction and widen the angle and mechanical separation of adhered angle tissues using instruments like goniosynechialysis hooks or iris repositors Surgical incision using instruments such as Microhook trabeculectomy hooks or cannulas can be performed to remove the diseased inner wall of Schlemms canal and the diseased trabecular meshwork either partially or circumferentially However the healing and outcomes of angle tissues following invasive angle interventions and their impact on surgical outcomes remain unclear Therefore our research team proposes to conduct imaging observation studies to track observe and quantify the status of the angle exploring the healing process of angle tissues This aims to provide theoretical support for the innovation and standardization of minimally invasive angle surgery
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None