Ignite Creation Date:
2024-07-17 @ 11:41 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06467305
Status:
RECRUITING
Last Update Posted:
2024-06-21
First Post:
2024-06-13
Brief Title:
Speech Motor Learning and Retention Aim 1
Sponsor:
Yale University
Organization:
Yale University
Study Overview
Official Title:
Sensorimotor Basis of Speech Motor Learning and Retention
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The overall goal of this research is to test a new model of speech motor learning whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation TMS Investigators will also use functional magnetic resonance imaging fMRI which will enable identification of circuit-level activity which predicts either learning or retention of new movements and hence test the specific contributions of candidate sensory and motor zones In other studies investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning
Detailed Description:
The focus of this registration is Aim 1 The work in Specific Aim 1 involves tests of speech motor memory retention following disruption of left hemisphere brain activity in either auditory somatosensory or motor cortex or to a control site hand area motor cortex right hemisphere Continuous theta-burst stimulation cTBS is delivered following adaptation to altered auditory feedback to assess its effects on the retention of new learning In the adaptation task participants read Harvard Sentences aloud which are presented on a computer monitor Vocal output is altered in real-time and played back to participants through headphones Tests of retention are conducted 24 hours later
The Speech Motor Learning and Retention Master Protocol has uniqueID 2000037622
The Speech Motor Learning and Retention Master Protocol has uniqueID 2000037622
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1R01DC022097-01A1 | OTHER_GRANT | None | None |