Ignite Creation Date:
2024-07-17 @ 11:42 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06484803
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-07-03
First Post:
2024-06-26
Brief Title:
Resilience Among Trauma Survivors
Sponsor:
Tel-Aviv Sourasky Medical Center
Organization:
Tel-Aviv Sourasky Medical Center
Study Overview
Official Title:
Longitudinal Search for Neurobehavioral Underpins of Resilience to Stress
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A major gap remains in understanding the neurobehavioral mechanism of individuals variability in the dynamic process of responding to traumatic events To address this gap the proposed study is focused on two dominant survival processes acute stress response and motivational behavior Investigating the involvement of these processes in long-term recovery from a documented traumatic event our study extends a prior longitudinal investigation in our lab that systematically assessed the neurobehavioral factors contributing to the development of PTSD
Detailed Description:
Individual responses to potentially traumatic stress exhibit wide variation reflecting differences in stress resilience - denoting the capacity to adaptively cope with and recover from adversity ie health despite adversity To date growing evidence tracing symptoms changes following a potentially traumatic event has revealed distinct clinical trajectories demonstrating variability in the individuals recovery dynamics following a traumatic event While some individuals regain homeostasis and recover over time others experience chronic debilitating dysfunctions and exhibit long-term psychopathology The current study aims to extend an original longitudinal investigation assessing recent trauma survivors three times within 14 months with additional clinical and neurobehavioral assessment time points at 80 months following the exposure to a documented traumatic event While the previous study focused on assessing neurobehavioral indications of threat and reward sensitivity this study specifically focused on acute stress response and motivational behavior with respect to trauma recovery trajectory
Acute stress response involves immediate neurophysiological and psychological reactions to perturbing occurrence transitioning from a reactive phase to a recovery phase The reactivity phase is characterized by a threat to physical and mental homeostasis manifested in multiple neurobiological processes Subsequently the stress response transitions to the recovery phase distinguished by restoring homeostasis and establishing a new memory for coping in the future The novel dataset collected in this study including fMRI task and resting state behavioral and biological measurements enables examination of the neurophysiological mechanism underlying lab-induced acute stress reactivity and recovery and associates it with long-term clinical outcomes following life event adversity Motivation plays a crucial role in driving the individuals behavior toward a desirable ie rewarding goal and assists in adaptive coping with the environment An intriguing finding in the original longitudinal study pointed to the importance of preserved reward processing for resilience However the study lacks an exploration of goal-based behavior in motivation which is critical for adaptive coping following stress eg deciding to make an effort and pursue rewarding stimuli despite the possibility of encountering an unpleasant occurrence such as a traumatic reminder In this project we posit neurobehavioral aspects of motivational goal-directed behavior as indicated by approaching or avoiding rewards under risk will be associated with the long-term dynamics of recovery among trauma survivors Neuronally the indicated stress and motivation processes are depicted by functionality patterns in circuits involved in stress and threat eg amygdala insula and periaqueductal gray PAG motivation eg ventral striatum orbital-PFC and Ventral Tegmental Area VTA and memory learning and emotion regulation eg hippocampus and ventromedial-PFC
In the current study participants from the initial longitudinal study were recruited for a fourth-time point 60 months following trauma exposure and a fifth-time point 80 months following trauma exposure The fourth evaluation point involved clinical assessment fMRI scan physiological measurements saliva collection for cortisol and blood sampling for epigenetic indices The fifth time point involved home-based self-report questionnaires to evaluate the impact of the October 7th 2023 events on the participants clinical status
Acute stress response involves immediate neurophysiological and psychological reactions to perturbing occurrence transitioning from a reactive phase to a recovery phase The reactivity phase is characterized by a threat to physical and mental homeostasis manifested in multiple neurobiological processes Subsequently the stress response transitions to the recovery phase distinguished by restoring homeostasis and establishing a new memory for coping in the future The novel dataset collected in this study including fMRI task and resting state behavioral and biological measurements enables examination of the neurophysiological mechanism underlying lab-induced acute stress reactivity and recovery and associates it with long-term clinical outcomes following life event adversity Motivation plays a crucial role in driving the individuals behavior toward a desirable ie rewarding goal and assists in adaptive coping with the environment An intriguing finding in the original longitudinal study pointed to the importance of preserved reward processing for resilience However the study lacks an exploration of goal-based behavior in motivation which is critical for adaptive coping following stress eg deciding to make an effort and pursue rewarding stimuli despite the possibility of encountering an unpleasant occurrence such as a traumatic reminder In this project we posit neurobehavioral aspects of motivational goal-directed behavior as indicated by approaching or avoiding rewards under risk will be associated with the long-term dynamics of recovery among trauma survivors Neuronally the indicated stress and motivation processes are depicted by functionality patterns in circuits involved in stress and threat eg amygdala insula and periaqueductal gray PAG motivation eg ventral striatum orbital-PFC and Ventral Tegmental Area VTA and memory learning and emotion regulation eg hippocampus and ventromedial-PFC
In the current study participants from the initial longitudinal study were recruited for a fourth-time point 60 months following trauma exposure and a fifth-time point 80 months following trauma exposure The fourth evaluation point involved clinical assessment fMRI scan physiological measurements saliva collection for cortisol and blood sampling for epigenetic indices The fifth time point involved home-based self-report questionnaires to evaluate the impact of the October 7th 2023 events on the participants clinical status
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None