Ignite Creation Date:
2024-07-17 @ 11:43 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06480929
Status:
COMPLETED
Last Update Posted:
2024-06-28
First Post:
2024-06-21
Brief Title:
LV Thrombus Screening in Anterior STEMI Worth it
Sponsor:
Centro Hospitalar Tondela-Viseu
Organization:
Centro Hospitalar Tondela-Viseu
Study Overview
Official Title:
Left Ventricular Thrombus Routine Screening With Contrast Echocardiography in Patients With Anterior ST-elevation Myocardial Infarction is it Worth it
Status:
COMPLETED
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
LVT-CE-AMI
Brief Summary:
Left ventricular LV thrombus is more common in patients with anterior ST-elevation myocardial infarction STEMI compared to other types of acute myocardial infarction AMI and is linked to worse outcomes Diagnosing LV thrombus remains challenging Contrast echocardiography TTE has potential to improve diagnostic accuracy affecting treatment strategies involving antithromboticanticoagulation therapy
This study aimed to evaluate the effectiveness of contrast TTE as a routine screening method for detecting LV thrombus in the acute phase of anterior STEMI
This study aimed to evaluate the effectiveness of contrast TTE as a routine screening method for detecting LV thrombus in the acute phase of anterior STEMI
Detailed Description:
The advent of primary percutaneous coronary intervention PCI has significantly lowered mortality rates associated with acute myocardial infarction AMI Despite these advancements post-infarction complications including left ventricular LV thrombus continue to negatively impact prognosis The incidence of LV thrombus has decreased due to improved reperfusion techniques and antithrombotic therapies however it remains a significant risk factor for embolic events with up to a 10 risk of stroke within a year despite anticoagulation therapy The formation of thrombus post-AMI particularly in anterior ST-elevation myocardial infarction STEMI is driven by endothelial injury blood stasis due to LV dysfunction and hypercoagulability from inflammation
Anterior STEMI usually caused by occlusion of the left anterior descending artery often leads to LV apical akinesia and subsequent thrombus formation within 24 hours to two weeks post-AMI Guidelines recommend routine transthoracic echocardiography TTE post-PCI to evaluate LV function and detect early post-infarction mechanical complications and LV thrombus However conventional TTE can be limited by operator skill and may miss thrombi especially in cases with suboptimal images or smallmural thrombi Advances in ultrasound technology including contrast agents have improved diagnostic accuracy for LV thrombus by enhancing LV opacification and endocardial border delineation thus identifying the characteristic filling defect of intracardiac thrombus
This study aimed to assess the effectiveness of contrast-enhanced TTE as a routine screening method for detecting LV thrombus in the acute phase of anterior STEMI
A prospective single-center randomized controlled trial was conducted with patients admitted for anterior STEMI at Centro Hospitalar de Tondela-Viseu from November 2021 to January 2023 Patients were randomly assigned to a study group undergoing contrast TTE or a control group undergoing conventional TTE Exclusion criteria included patients under 18 those without echocardiographic or coronary angiographic evaluation those with cardiogenic shock known thrombus or allergic reactions to contrast agents Contrast TTE utilized the SonoVue ultrasound agent and GE i9 echocardiograph performed by specialized cardiologists Data collected included demographic clinical and procedural information with statistical analysis comparing the characteristics and outcomes between the two groups
Anterior STEMI usually caused by occlusion of the left anterior descending artery often leads to LV apical akinesia and subsequent thrombus formation within 24 hours to two weeks post-AMI Guidelines recommend routine transthoracic echocardiography TTE post-PCI to evaluate LV function and detect early post-infarction mechanical complications and LV thrombus However conventional TTE can be limited by operator skill and may miss thrombi especially in cases with suboptimal images or smallmural thrombi Advances in ultrasound technology including contrast agents have improved diagnostic accuracy for LV thrombus by enhancing LV opacification and endocardial border delineation thus identifying the characteristic filling defect of intracardiac thrombus
This study aimed to assess the effectiveness of contrast-enhanced TTE as a routine screening method for detecting LV thrombus in the acute phase of anterior STEMI
A prospective single-center randomized controlled trial was conducted with patients admitted for anterior STEMI at Centro Hospitalar de Tondela-Viseu from November 2021 to January 2023 Patients were randomly assigned to a study group undergoing contrast TTE or a control group undergoing conventional TTE Exclusion criteria included patients under 18 those without echocardiographic or coronary angiographic evaluation those with cardiogenic shock known thrombus or allergic reactions to contrast agents Contrast TTE utilized the SonoVue ultrasound agent and GE i9 echocardiograph performed by specialized cardiologists Data collected included demographic clinical and procedural information with statistical analysis comparing the characteristics and outcomes between the two groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None