Ignite Creation Date:
2024-07-17 @ 11:44 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06489067
Status:
RECRUITING
Last Update Posted:
2024-07-05
First Post:
2024-06-26
Brief Title:
Study of the Thyroid Function and Echostructural Morphology in Patients Affected With Rasopathies ECORAS2023
Sponsor:
University of Bari Aldo Moro
Organization:
University of Bari Aldo Moro
Study Overview
Official Title:
Study of the Thyroid Function and Echostructural Morphology in Patients Affected With Rasopathies An Italian Multicenter Study
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ECORAS2023
Brief Summary:
The study aims to evaluate the prevalence of thyroid disease particularly with autoimmune pathogenesis isolated hyperthyrotropinemia hyperthyroidism hypothyroidism thyroid nodules andor morphostructural abnormalities of the thyroid gland in patients with RASopathy genetically confirmed by NGS technique analysis of the genes BRAF CBL HRAS KRAS LZTR1 MAP2K1 MAP2K2 MRAS NRAS PPP1CB PTPN11 RAF1 RIT1 RRAS2 SHOC2 SOS1 SOS2 and to compare the data obtained in our sample with those of the general population
The secondary aim of the study is to evaluate the association between vitamin D deficiency andor other abnormalities of bone metabolism and thyroid disease andor morphostructural anomalies of the thyroid gland in patients with RASopathy
The secondary aim of the study is to evaluate the association between vitamin D deficiency andor other abnormalities of bone metabolism and thyroid disease andor morphostructural anomalies of the thyroid gland in patients with RASopathy
Detailed Description:
All patients will undergo blood sampling aimed at studying thyroid function and autoimmunity TSH fT3 fT4 anti-TPO anti-TG anti-TSH receptor antibodies and biomarkers of bone metabolism calcium phosphorus ALP isoenzyme bone PTH osteocalcin vitamin D and a systematic color Doppler ultrasound examination of the thyroid gland in order to evaluate dimensions echostructure and echogenicity of the thyroid parenchyma presence of nodular lesions vascularization and laterocervical lymphadenopathy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None