Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005535
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Gene Mapping for Quantitative Traits
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2002-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To conduct gene mapping studies for quantitative traits
Detailed Description:
DESIGN NARRATIVE
The study built upon existing sib-pair methods for multipoint mapping of Quantitative Trait Loci QTLs It greatly expanded upon the statistical methodology to identify and localize QTLs for complex traits by merging sib-pair methods with a powerful twin design which used phenotypic data on monozygotic identical and dizygotic fraternal twins to resolve phenotypic variability into genetic and non-genetic components and partition human quantitative genetic variation into effects due to loci on specific chromosomal regions This quantitative methodology was applied to risk factors for cardiovascular disease -- one of the most pressing health problems in Western society Population-based samples of Dutch Swedish and Australian twins had been identified in previous studies phenotypic measures on lipids lipoproteins and other important cardiovascular risk factors had been obtained and blood had been banked in a valuable resource which was available for use in this study In 500 DZ twin pairs a series of 175 highly polymorphic microsatellite markers were detected using an automated process for detecting fluorescent signals These data were analyzed using the new statistical methods both to confirm the effects of a series of candidate loci and to test for the effects of previously unknown QTLs
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
The study built upon existing sib-pair methods for multipoint mapping of Quantitative Trait Loci QTLs It greatly expanded upon the statistical methodology to identify and localize QTLs for complex traits by merging sib-pair methods with a powerful twin design which used phenotypic data on monozygotic identical and dizygotic fraternal twins to resolve phenotypic variability into genetic and non-genetic components and partition human quantitative genetic variation into effects due to loci on specific chromosomal regions This quantitative methodology was applied to risk factors for cardiovascular disease -- one of the most pressing health problems in Western society Population-based samples of Dutch Swedish and Australian twins had been identified in previous studies phenotypic measures on lipids lipoproteins and other important cardiovascular risk factors had been obtained and blood had been banked in a valuable resource which was available for use in this study In 500 DZ twin pairs a series of 175 highly polymorphic microsatellite markers were detected using an automated process for detecting fluorescent signals These data were analyzed using the new statistical methods both to confirm the effects of a series of candidate loci and to test for the effects of previously unknown QTLs
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL055976 | NIH | None | httpsreporternihgovquickSearchR01HL055976 |