Ignite Creation Date:
2024-07-17 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06501222
Status:
RECRUITING
Last Update Posted:
2024-07-15
First Post:
2024-06-16
Brief Title:
The Renal Protective Effects of Remote Ischemic Preconditioning in Patients With Chronic Kidney Disease
Sponsor:
Yuanjun Yang
Organization:
Chinese PLA General Hospital
Study Overview
Official Title:
The Renal Protective Effects of Remote Ischemic Preconditioning in Patients With Chronic Kidney Disease Randomized Parallel-controlled proof-of Concept Trial
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The incidence of Chronic kidney disease CKD is showing an upward trend but the therapeutic effect of treatment is limited Remote ischemic conditioning RIC has the potential to safeguard remote organs via the repeated application of brief ischemic stimuli the aim of our study is to investigate whether RIC can protect the renal function in patients with CKD
Detailed Description:
Chronic kidney disease CKD is characterized by progressive and irreversible loss of nephrons Currently due to the increasing prevalence of diabetes hypertension obesity and the impact of population aging the incidence of CKD is showing an upward trend The treatment of CKD is mostly aimed at delaying the progression of renal function but the therapeutic effect is limited causing a continuous economic burden for CKD patients Therefore there is an urgent need to develop new treatment methods to prevent or reverse the progression of the disease
Remote ischemic conditioning RIC is a process that involves repeatedly applying brief ischemic stimuli to a certain organ or tissue which stimulates the bodys endogenous anti-ischemic injury ability enabling other organs or tissues besides the stimulated one to adapt to ischemia and improve their tolerance to ischemic injury thereby reducing the damage caused by ischemia to relevant organs or tissues Current studies have confirmed that RIC can protect remote organs such as the heart brain and kidneys through multiple pathways including humoral mechanisms neural conduction regulation mechanisms and immune inflammatory regulation mechanisms However current research in the field of kidney diseases has been mostly limited to acute kidney injury caused by contrast agents surgery etc and there are no reports on the intervention and treatment of CKD patients using RIC Therefore exploring whether RIC can delay the progression of renal function in CKD patients is of great significance
Remote ischemic conditioning RIC is a process that involves repeatedly applying brief ischemic stimuli to a certain organ or tissue which stimulates the bodys endogenous anti-ischemic injury ability enabling other organs or tissues besides the stimulated one to adapt to ischemia and improve their tolerance to ischemic injury thereby reducing the damage caused by ischemia to relevant organs or tissues Current studies have confirmed that RIC can protect remote organs such as the heart brain and kidneys through multiple pathways including humoral mechanisms neural conduction regulation mechanisms and immune inflammatory regulation mechanisms However current research in the field of kidney diseases has been mostly limited to acute kidney injury caused by contrast agents surgery etc and there are no reports on the intervention and treatment of CKD patients using RIC Therefore exploring whether RIC can delay the progression of renal function in CKD patients is of great significance
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None