Ignite Creation Date:
2024-07-17 @ 11:53 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06495151
Status:
COMPLETED
Last Update Posted:
2024-07-12
First Post:
2024-07-03
Brief Title:
Endometriosis and Complement System
Sponsor:
Ankara City Hospital Bilkent
Organization:
Ankara City Hospital Bilkent
Study Overview
Official Title:
Evaluation of Serum and Peritoneal Fluid Mannose-binding Lectin Associated Serine Protease-3 Adipsin Properdin and Complement Factor H Levels in Endometriosis Patients
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Endometriosis is a chronic gynecological condition affecting nearly 10 of women of reproductive age A definitive diagnosis of endometriosis requires laparoscopy Studies aim to identify novel biomarkers to aid in the development of effective noninvasive diagnostic methods Despite several theories the full understanding of the etiopathogenesis remains elusive A distorted immune response is thought to play a crucial role in the pathophysiology of endometriosis This study aimed to evaluate whether the levels of alternative complement molecules change in the blood serum and peritoneal fluid of endometriosis patients compared to healthy subjects
Detailed Description:
Endometriosis is a chronic gynecological condition affecting nearly 10 of women of reproductive age It has been reported to contribute to 21-47 of cases of female infertility and 71-87 of cases involving chronic pelvic pain The definitive diagnosis of endometriosis requires laparoscopy While CA-125 has diagnostic value it is not specific to endometriosis Therefore studies are focused on identifying novel biomarkers to aid in the development of effective noninvasive diagnostic methods Despite numerous theories the etiopathogenesis of endometriosis remains incompletely understood A distorted immune response is believed to play a crucial role in the pathophysiology of the condition Regarding alterations in the classical and lectin-dependent complement systems C3a C3c C4 and C5b-9 have been suggested to hold potential diagnostic value in endometriosis Alternative pathway is another way for complement activation This study aimed to investigate whether there are alterations in the levels of alternative complement molecules in both the blood serum and peritoneal fluid of patients diagnosed with endometriosis comparing these levels to those found in healthy individuals The research focused on understanding potential differences that could contribute to the pathophysiology of endometriosis aiming to provide insights into the role of the alternative complement pathway in this gynecological condition
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None