Ignite Creation Date:
2024-07-17 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06482138
Status:
RECRUITING
Last Update Posted:
2024-07-01
First Post:
2024-02-19
Brief Title:
Dysfunction of Olfaction After COVID-19 Infection Morphological and Histomolecular Investigation
Sponsor:
Universitaire Ziekenhuizen KU Leuven
Organization:
Universitaire Ziekenhuizen KU Leuven
Study Overview
Official Title:
Dysfunction of Olfaction After SARS-CoV-2 Infection Morphological and Histomolecular Investigation of Olfactory Cleft Biopsies and Cytobrushes
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DysOSMIC
Brief Summary:
Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction OD in patients with well-documented olfactory function The investigators plan to collect olfactory cleft biopsies and cytobrushes in COVID-19 patients and controls
Detailed Description:
An explorative prospective clinical study using human body materials of living post-COVID-19 patients with and without OD to study the mechanisms of persisting olfactory dysfunction Patients consult ENT specialist for medical purposes and undergo standard-of-care diagnostics and management The collected tissues from the olfactory cleft mucosa will be analyzed using single cell RNA sequencing and RNAscope combined with immunohistochemistry
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None