Ignite Creation Date:
2024-07-17 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06493396
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-10
First Post:
2024-07-02
Brief Title:
Effect of Opioid-free Anesthesia on Sleep Quality Cognitive Function and Recovery Quality After General Anesthesia in Elderly Patients
Sponsor:
Beijing Friendship Hospital
Organization:
Beijing Friendship Hospital
Study Overview
Official Title:
Effect of Opioid-free Anesthesia on Sleep Quality Cognitive Function and Recovery Quality After General Anesthesia in Elderly Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Postoperative cognitive dysfunction POCDis a common well disorder of the central nervous system after surgery mainly manifested by impaired memory spirit language ability or other aspects of brain function POCD which often occurs in elderly patients over 65 years The recent phase is recommended to be changed to perioperative neurocognitive impairment PND The PND is used to describe the cognitive function changes that occur before and within 1 year after surgery Based on the time of disease onset It can be divided into neurocognitive impairment existing before surgery postoperative delusion POD occurring hours to days after surgery neurocognitive recovery delay DNR within 30 days after surgery and postoperative neurocognitive impairment occurring weeks to months after surgery POND With the acceleration of the aging process of Chinese social population the frequency of surgical treatment for elderly inpatients has also increased and the elderly patients have postoperative sleep disorders and POCD is relatively common Surgical patients after surgical trauma the body inflammation sympathetic excitation and endocrine disorders make postoperative sleep structure or pattern change often lead to postoperative sleep disorders PSD the main performance for patients with postoperative complaint difficult to enter and maintain sleep frequent nightmares total sleep quantity and quality reduction etc PSD is not only the most common manifestation of postoperative brain dysfunction but also an important risk factor for inducing postoperative fatigue postoperative hyperalgesia metabolic dysfunction and cardiovascular and cerebrovascular diseases Moreover it is considered to promote the development of postoperative delusion At present the common mode of general anesthesia is still mainly opioids and opioids are an important part of general anesthesia and perioperative analgesia Perioperative use of opioids is not only associated with adverse effects such as postoperative nausea and vomiting excessive sedation and ileus but also leads to the occurrence of postoperative hypoxemia hyperalgesia and postoperative chronic pain and cognitive impairment Therefore the Association of Accelerated Rehabilitation Surgery indicates that the use of a multimodal analgesic regimen during the perioperative period reduces pain and reduces opioid-related adverse effects and that opioid-free anesthesia OFA is used in clinical work At present most clinical studies of OFA focus on adults aged 18-65 or 18 years old and few studies focus OFA solely on the elderly population to observe its application effect Therefore it is necessary to conduct clinical studies to observe postoperative recovery in elderly patients with different types of anesthetics investigate the incidence and severity of POCD and determine the efficacy and safety of each anesthetic agent
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None