Ignite Creation Date:
2024-07-17 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06491485
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-09
First Post:
2024-07-01
Brief Title:
Postoperative Analgesia in Laparoscopic Gynecological Surgeries
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Magnesium Sulfate Versus Sodium Bicarbonate as Adjuvants to Lidocaine 1 by Intraperitoneal Instillation for Postoperative Analgesics in Laparoscopic Gynecological Surgeries
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to compare intraperitoneal instillation of magnesium sulfate versus sodium bicarbonate as an adjuvant to lidocaine 1 on reducing postoperative pain in laparoscopic gynecological surgeries
Detailed Description:
Patients undergoing laparoscopic surgery experience postoperative pain especially in the abdomen lower back and shoulders Relieving postoperative pain especially with certain types of analgesic agents may reduce postoperative morbidity and mortality It is also important to prevent adverse events such as myocardial infarction cardiac arrhythmia ileus and poor wound healing and pulmonary complications There is evidence that the main source of pain after laparoscopic surgeries is the peritoneum Due to CO2 insufflation constitutes the commonest means of creating the pneumoperitoneum Co2pneumoperitoneum is known to cause systemic acidosis Which is responsible for damaging of the mesothelial lining of the peritoneum and consequent peritoneal irritation Moreover the phrenic nerve could be damaged by the acidic environment The use of local anesthetics has been advocated as a method for reducing postoperative pain local anesthetic intraperitoneal administration has shown good effects on reducing postoperative pain in laparoscopic cholecystectomy and gynecological surgeries intraperitoneal sodium bicarbonate instillation may neutralize effect of the acid milieu on peritoneal cavity and the phrenic nerve damage which consecutively will lead to a reduction of postoperative pain Magnesium sulfate a non-competitive NMDA antagonist has been proven in animal and human being models to have antinociceptive properties The antinociceptive effect of magnesium sulfate relieves chronic pain and it can also decrease the duration and intensity of postoperative pain
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None