Ignite Creation Date:
2024-07-17 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06473896
Status:
RECRUITING
Last Update Posted:
2024-06-25
First Post:
2024-06-19
Brief Title:
Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Following Treatment With Remifentanil
Sponsor:
Assaf-Harofeh Medical Center
Organization:
Assaf-Harofeh Medical Center
Study Overview
Official Title:
Comparison of the Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Induced Following Treatment With Remifentanil in Patients Undergoing a Laparoscopic Cholecystectomy
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Analgesia is one of the pillars of anesthesia One of the common opiates for pain relief with a short half-life is Remifentanil However following Remifentanil treatment an increased sensitivity to pain hyperalgesia appears The aim of the study is to compare the effects between complementary treatments like Ketalar and Dexmedetomidine in preventing increased sensitivity to pain after Remifentanil treatment
Detailed Description:
Analgesia is one of the pillars of anesthesia For many years opiates were the basic ingredient in pain relief The effectiveness of these substances in pain relief caused them to be overused which resulted in a global epidemic of addiction morbidity and mortality due to the overuse of these drugs Some of the options for realizing a reduction in the use of opiates include the use of drugs with a more predictable pharmacological profile and a short half-life such as Remifentanil This opiate is stronger than Morphine and its half-life remains within a few minutes without accumulation even after prolonged infusion Therefore it seems that the use of remifentanil is ideal especially for prolonged anesthesia
One of the severe complications following treatment with Remifentanil is the appearance of increased sensitivity to pain hyperalgesia which results from a central sensitivity to pain and is expressed by stimulation of sensory receptors for pain in the nervous system nociceptive sensitization In order to alleviate the feeling of pain following the increased sensitivity to pain after treatment with opiates as well as with Remifentanil complementary treatments such as Ketalar and dexmedetomidine were offered This study will compare the ability of Ketalar or Dexmedetomidine in alleviating increased sensitivity to pain after treatment with Remifentanil in patients who are candidates for laparoscopic cholecystectomy
One of the severe complications following treatment with Remifentanil is the appearance of increased sensitivity to pain hyperalgesia which results from a central sensitivity to pain and is expressed by stimulation of sensory receptors for pain in the nervous system nociceptive sensitization In order to alleviate the feeling of pain following the increased sensitivity to pain after treatment with opiates as well as with Remifentanil complementary treatments such as Ketalar and dexmedetomidine were offered This study will compare the ability of Ketalar or Dexmedetomidine in alleviating increased sensitivity to pain after treatment with Remifentanil in patients who are candidates for laparoscopic cholecystectomy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None