Ignite Creation Date:
2024-07-17 @ 11:57 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06501521
Status:
RECRUITING
Last Update Posted:
2024-07-15
First Post:
2024-07-01
Brief Title:
Non-invasive Brain Tumor Molecular Diagnostics and Monitoring
Sponsor:
The Institute of Molecular and Translational Medicine Czech Republic
Organization:
The Institute of Molecular and Translational Medicine Czech Republic
Study Overview
Official Title:
Non-invasive Brain Tumor Diagnosis Through Analysis of Proximal Fluids Circulating Tumor Cells and Biomolecules
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This prospective multicenter study aims to enroll GBM patients who will undergo repeated assessments preoperatively and 3 months post-surgery to detect circulating tumor cells and analyze the transcriptomic profiles of EVs in their blood The prognostic and monitoring significance of these biomarkers to disease course assessing treatment efficacy resistance incidence tumor progression will be evaluated
Concurrently proteomic profiles typical of GBM will be analyzed in blood and ocular secretion samples from GBM patients patients with low-grade gliomas and patients without brain tumors to identify and validate novel protein biomarkers suitable for disease monitoring Additionally this study proposes an innovative approach to monitor GBM patients by investigating the presence of GBM-specific nucleic acid fragments in urine
Concurrently proteomic profiles typical of GBM will be analyzed in blood and ocular secretion samples from GBM patients patients with low-grade gliomas and patients without brain tumors to identify and validate novel protein biomarkers suitable for disease monitoring Additionally this study proposes an innovative approach to monitor GBM patients by investigating the presence of GBM-specific nucleic acid fragments in urine
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None