Ignite Creation Date:
2024-07-17 @ 11:58 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06495255
Status:
RECRUITING
Last Update Posted:
2024-07-10
First Post:
2024-05-14
Brief Title:
Bioavailability of Human Milk Oligosaccharides in Healthy Adults
Sponsor:
University of Bonn
Organization:
University of Bonn
Study Overview
Official Title:
Bioavailability of Human Milk Oligosaccharides in Healthy Adults
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Human milk oligosaccharides HMOs have been associated with beneficial health outcomes in breastfed infants therefore they were investigated intensively within recent years HMOs support the establishment of a balanced intestinal microbiome by acting as both a prebiotic and as a specific antimicrobial In vitro work has demonstrated that HMOs are resistant to hydrolysis by salivary pancreatic and brush-border enzymes as well as to low gastric pH values enzymes Consequently HMOs are mostly resistant to digestion and reach the colon unmodified where they are available for selective utilisation by certain bacteria Microbial utilisation results in the formation of microbial metabolites which are associated with local and systemic effects Simultaneously HMOs have bacteriostatic effects and directly limit the growth of potential pathogens Moreover they serve as antiadhesives mimicking intestinal epithelial cell surface receptors to which pathogenic microbes attach thus acting as a decoy receptor Additionally it is suggested that HMOs exert effects independent of the microbiome by modulating cell recognition and cell signalling These include interactions with immune cells thereby modulating the development and responses of the immune system the maturation of the intestinal glycocalyx and the promotion of neurodevelopment and cognitive functions A prerequisite for systemic effects is that HMOs are absorbed and can enter the blood circulation thus making them potentially available at the systemic level In order to understand the underlying mechanisms for HMO-mediated microbe-independent effects information regarding absorption metabolisation and excretion is needed and will be investigated in this study
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None