Ignite Creation Date:
2024-07-17 @ 12:01 PM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06493929
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-10
First Post:
2024-07-02
Brief Title:
Mechanical Power as a Predictor for Weaning in Chronic Obstructive Pulmonary Disease Patients Prospective Cohort Study
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Mechanical Power as a Predictor for Weaning in Chronic Obstructive Pulmonary Disease Patients Prospective Cohort Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The primary objective is to evaluate the mechanical power as a predictor of weaning of mechanical ventilation in COPD patients hospitalized in the respiratory intensive care unit of Assiut University Hospital The secondary objective is to compare between mechanical power and diaphragmatic excursion DE assessed by ultrasound as a predictor of weaning in these patients Also to investigate the association between MP and DE and mortality in these patients
Detailed Description:
Acute exacerbation of chronic obstructive pulmonary disease AECOPD a public health problem that is characterized by persistent airflow limitation it develops when there is a significant exposure of irritants causing an inflammatory response in the lungs it is a common cause of respiratory failure which require hospital admission that is associated with increased medical costs
The World Health Organization reported that COPD was the fifth most common disease globally in 2020 with a prevalence of 78-197 in adults Approximately 60 of patients with COPD admitted with hypercapnic respiratory failure
Acute exacerbations of chronic obstructive pulmonary disease COPD is characterized by acute worsening of respiratory symptoms associated with the development of severe airflow limitation gas trapping dynamic hyperinflation and intrinsic positive end-expiratory pressure PEEPi In the most severe cases these exacerbations may cause acute respiratory failure which may require mechanical ventilation
The process of weaning from mechanical ventilation remains one of the most critical challenges in patients underwent mechanical ventilation in the intensive care unit ICU The multidisciplinary team must study the optimal time for weaning from the mechanical ventilator as premature weaning may lead to weaning failure and thus increase the risk of hospital acquired infections costs of care length of ICU stay Morbidity and Mortality
Current guidelines recommend several indices applied at the bedside to predict successful weaning from mechanical ventilation A spontaneous breathing trial SBT is an appropriate way to prepare the patient for extubation however even after successful SBT failure rates and subsequent reintubation can exceed 20 in the highest-risk patient
Mechanical power MP is the energy delivered by the ventilator to the entire respiratory system per time unit and combines all factors affecting the energy load of the respiratory system including pressure tidal volume flow rate and respiratory rate
MP is primarily calculated as the product of the applied airway pressure and minute ventilation and can be used as an estimate of the workload exerted on the respiratory muscles during spontaneous breathing
MP is a major determinant to ensure adequate gas exchange in the body and a key factor in assessing the ability of a patient to successfully wean from mechanical ventilation
Therefore a larger scale clinical study is needed to further verify the relationship between MP and weaning outcomes in all critically ill mechanically ventilated patients
The World Health Organization reported that COPD was the fifth most common disease globally in 2020 with a prevalence of 78-197 in adults Approximately 60 of patients with COPD admitted with hypercapnic respiratory failure
Acute exacerbations of chronic obstructive pulmonary disease COPD is characterized by acute worsening of respiratory symptoms associated with the development of severe airflow limitation gas trapping dynamic hyperinflation and intrinsic positive end-expiratory pressure PEEPi In the most severe cases these exacerbations may cause acute respiratory failure which may require mechanical ventilation
The process of weaning from mechanical ventilation remains one of the most critical challenges in patients underwent mechanical ventilation in the intensive care unit ICU The multidisciplinary team must study the optimal time for weaning from the mechanical ventilator as premature weaning may lead to weaning failure and thus increase the risk of hospital acquired infections costs of care length of ICU stay Morbidity and Mortality
Current guidelines recommend several indices applied at the bedside to predict successful weaning from mechanical ventilation A spontaneous breathing trial SBT is an appropriate way to prepare the patient for extubation however even after successful SBT failure rates and subsequent reintubation can exceed 20 in the highest-risk patient
Mechanical power MP is the energy delivered by the ventilator to the entire respiratory system per time unit and combines all factors affecting the energy load of the respiratory system including pressure tidal volume flow rate and respiratory rate
MP is primarily calculated as the product of the applied airway pressure and minute ventilation and can be used as an estimate of the workload exerted on the respiratory muscles during spontaneous breathing
MP is a major determinant to ensure adequate gas exchange in the body and a key factor in assessing the ability of a patient to successfully wean from mechanical ventilation
Therefore a larger scale clinical study is needed to further verify the relationship between MP and weaning outcomes in all critically ill mechanically ventilated patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None