Ignite Creation Date:
2024-10-25 @ 7:49 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06589674
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-06
Brief Title:
Comparison of Pleth Variability Index Vs Diastolic Shock Index for Predicting Hypotension During Anesthesia Induction
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Comparison of the Effectiveness of Pleth Variability Index and Diastolic Shock Index in Predicting Hypotension During Anesthesia Induction
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to explore the frequent occurrence of hypotension during anesthesia induction due to anesthetic drugs or fasting Predicting this condition is important for patient safety and anesthesia management The study examines two indices the Pleth Variability Index PVI derived from pulse oximeter readings and the Diastolic Shock Index DSI calculated using heart rate and diastolic blood pressure While PVI is a well-known method DSI has been less explored in predicting anesthesia-related hypotension The study aims to compare the effectiveness of these two indices in forecasting hypotension during anesthesia induction
Detailed Description:
Hypotension is frequently observed during anesthesia induction due to the effects of anesthetic drugs on hemodynamics and the requirement of a specific fasting period before surgery Induction-related hypotension can lead to decreased tissue perfusion and consequently secondary organ damage Predicting anesthesia-induced hypotension in advance contributes to better anesthesia management and patient safety 1 Induction-related hypotension is defined as arterial hypotension occurring within the first 20 minutes after anesthesia induction or until the start of the surgery Arterial hypotension is identified when systolic blood pressure SBP lt 90 mmHg or when norepinephrine is administered at a dose gt6 mcgmin at least once during this period 2
The peripheral perfusion index PI is a simple cost-effective monitoring method derived from non-invasive plethysmographic data using pulse oximetry It provides an assessment of fluid status based on respiratory changes in pulse oximeter waves with higher PI values indicating lower arterial tone Changes in PI are interpreted as signs of vascular tone or fluid deficit issues in patients The ratio of the highest and lowest PI values yields the Pleth Variability Index PVI 34 PVI can be used to predict hypotension during anesthesia induction 5
Cardiac output CO is calculated by multiplying systemic vascular resistance SVR and heart rate HR In septic and shock patients CO may be low often due to decreased SVR The autonomic system tries to maintain CO by increasing HR in response to the reduced SVR 6 Systolic and diastolic shock indices are obtained by dividing the HR by systolic and diastolic blood pressures respectively The diastolic shock index has been evaluated in studies to predict vasopressor response in septic patients 7 A high shock index has been associated with early vasopressor initiation and better prognosis However no study has yet examined the predictive power of the diastolic shock index which is related to sympathetic response and systemic vascular resistance for hypotension following anesthesia induction
Moreover the diastolic shock index has not been compared with the more commonly used PVI in terms of their ability to predict hypotension Therefore our study aims to test the success of diastolic shock index and PVI measurements in predicting anesthesia-induced hypotension
The peripheral perfusion index PI is a simple cost-effective monitoring method derived from non-invasive plethysmographic data using pulse oximetry It provides an assessment of fluid status based on respiratory changes in pulse oximeter waves with higher PI values indicating lower arterial tone Changes in PI are interpreted as signs of vascular tone or fluid deficit issues in patients The ratio of the highest and lowest PI values yields the Pleth Variability Index PVI 34 PVI can be used to predict hypotension during anesthesia induction 5
Cardiac output CO is calculated by multiplying systemic vascular resistance SVR and heart rate HR In septic and shock patients CO may be low often due to decreased SVR The autonomic system tries to maintain CO by increasing HR in response to the reduced SVR 6 Systolic and diastolic shock indices are obtained by dividing the HR by systolic and diastolic blood pressures respectively The diastolic shock index has been evaluated in studies to predict vasopressor response in septic patients 7 A high shock index has been associated with early vasopressor initiation and better prognosis However no study has yet examined the predictive power of the diastolic shock index which is related to sympathetic response and systemic vascular resistance for hypotension following anesthesia induction
Moreover the diastolic shock index has not been compared with the more commonly used PVI in terms of their ability to predict hypotension Therefore our study aims to test the success of diastolic shock index and PVI measurements in predicting anesthesia-induced hypotension
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None