Ignite Creation Date:
2024-10-25 @ 7:51 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06511492
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-16
Brief Title:
Longitudinal Surveillance of Rectal Colonization and Transmission by Resistant Bacteria in Acutely Decompensated Cirrhosis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Longitudinal Surveillance of Rectal Colonization and Transmission by Resistant Bacteria in Acutely Decompensated Cirrhosis a Cohort Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Antimicrobial resistance has emerged as a global threat and multidrug resistance organisms MDROs form one of the foremost challenges in the setting of decompensated cirrhosis In a worldwide study a high prevalence 34 of infection with MDR bacteria in patients with cirrhosis and associated with higher in-hospital mortality
Previous study indicated that the pattern of colonized bacteria in heterogeneous and the colonization by MDROs is associated with increased risk of infection Effort should be made to reduce the spread of MDR bacteria and improvement in prognosis in patents with cirrhosis Currently strategies suggested to prevent the spread of MDROs in cirrhosis including rapid microbiological tests new first-line antibiotic schedules infection control practices and epidemiological surveillance
Thus for the aims of this cohort study are as following Firstly to characterize the burden dynamics and risk factors associated with rectal colonization by MDROs in patients with cirrhosis Secondly to completely characterize the risk that asymptomatic carriers of MDROs both to other patients and to themselves via collecting detailed longitudinal sampling and high-resolution typing Lastly to generate evidence for future policymaking for individualized antimicrobial decision rather than umbrella guidelines since the variance in the bacteriological profiles in different settings
Previous study indicated that the pattern of colonized bacteria in heterogeneous and the colonization by MDROs is associated with increased risk of infection Effort should be made to reduce the spread of MDR bacteria and improvement in prognosis in patents with cirrhosis Currently strategies suggested to prevent the spread of MDROs in cirrhosis including rapid microbiological tests new first-line antibiotic schedules infection control practices and epidemiological surveillance
Thus for the aims of this cohort study are as following Firstly to characterize the burden dynamics and risk factors associated with rectal colonization by MDROs in patients with cirrhosis Secondly to completely characterize the risk that asymptomatic carriers of MDROs both to other patients and to themselves via collecting detailed longitudinal sampling and high-resolution typing Lastly to generate evidence for future policymaking for individualized antimicrobial decision rather than umbrella guidelines since the variance in the bacteriological profiles in different settings
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None