Ignite Creation Date:
2024-10-25 @ 7:51 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06550167
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-06-13
Brief Title:
Neuroprotective Effect of Nano PSO in Patients Who Used to Consume Psychoactive Substances
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Neuroprotective Effect of Omega Nano PSO Changes in Neurotrophic BDNF and VEGF and Their Association With Cognitive Status in Patients Who Used to Consume Psychoactive Substances
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Addiction problems to psychoactive substances are becoming more frequent which implies a serious health problem with social family and work repercussions Participants with chronic consumption present important degeneration processes mediated by Neuroinflammation oxidative stress and excitotoxicity At the moment there is no effective treatment that can reduce the damage The effectiveness of Omega 5 has been demonstrated in different disorders of the nervous system However very little has been elucidated about the mechanisms of regulation and activation in consumer patients Omega 5 Nano-PSO has an important role in mechanisms of cell survival in different pathological events
In this project aims to explain the possible mechanisms underlying the morphological changes and pathologies associated with oxidative stress and inflammation since it could be a useful strategy to counteract the effects of substances of abuse on brain cells
Omega 5 Nano PSO will modify the levels of neurotrophic factors through the decrease in inflammation and reactive oxygen species in patient-consumers of substances reducing neuronal death and therefore cognitive deterioration Methodological design Type of study Clinical trial randomized controlled double blind Research Headquarters This work will be carried out at the University Center for Health Science with the participation of the My family is waiting for me rehabilitation centers Study Period 2 years
In this project aims to explain the possible mechanisms underlying the morphological changes and pathologies associated with oxidative stress and inflammation since it could be a useful strategy to counteract the effects of substances of abuse on brain cells
Omega 5 Nano PSO will modify the levels of neurotrophic factors through the decrease in inflammation and reactive oxygen species in patient-consumers of substances reducing neuronal death and therefore cognitive deterioration Methodological design Type of study Clinical trial randomized controlled double blind Research Headquarters This work will be carried out at the University Center for Health Science with the participation of the My family is waiting for me rehabilitation centers Study Period 2 years
Detailed Description:
Omega 5 Nano PSO has been shown to be a powerful antioxidant with neuroprotective and anti-inflammatory effects in various neurological and neurodegenerative diseases In patients who consume psychoactive substances who present high levels of neuroinflammation and oxidative stress Omega 5 could help to reduce damage on neuronal and glial cells promoting cell survival and preserving a homeostatic microenvironment in the brain
It has been suggested that Omega 5 could modify the levels of neurotrophic factors such as BDNF and VEGF which might contribute to the protection of brain cells and the improvement of cognitive status in substance abuse patients In addition it has been mentioned that Omega 5 acts through the reduction of inflammation and reactive oxygen species which could reduce neuronal death and prevent cognitive deterioration in these patients
In summary Omega 5 Nano PSO seems to play an important role in protecting the brain cells of patients who consume psychoactive substances by acting as an antioxidant and anti-inflammatory modulating neurotrophic factors and promoting cell survival in a brain environment affected by substance consumption
It has been investigated that Omega 5 Nano PSO exerts its beneficial effects through various regulation and activation mechanisms in patients who consume psychoactive substances
1 Modulation of neurotrophic factors It has been suggested that Omega 5 can modify the levels of neurotrophic factors such as brain-derived neurotrophic factor BDNF and vascular endothelial growth factor VEGF in patients who consume psychoactive substances These factors play a crucial role in the neuroprotection and its modulation by Omega 5 could contribute to the improvement of cognitive status and cell survival in these patients
2 Antioxidant and anti-inflammatory action Omega 5 has been shown to have antioxidant and anti-inflammatory effects in several pathologies of the nervous system In patients who consume psychoactive substances who have high levels of neuroinflammation and oxidative stress Omega 5 can help reduce damage to neuronal and glial cells promoting cell survival and preserving a homeostatic brain environment
3 Protection against oxidative stress It has been suggested that Omega 5 may be useful to reduce the damage caused by oxidative stress at the brain level in substance abuse patients By acting as an antioxidant Omega 5 could counteract the negative effects of oxidative stress on brain cells and contribute to neuronal protection
It has been suggested that Omega 5 could modify the levels of neurotrophic factors such as BDNF and VEGF which might contribute to the protection of brain cells and the improvement of cognitive status in substance abuse patients In addition it has been mentioned that Omega 5 acts through the reduction of inflammation and reactive oxygen species which could reduce neuronal death and prevent cognitive deterioration in these patients
In summary Omega 5 Nano PSO seems to play an important role in protecting the brain cells of patients who consume psychoactive substances by acting as an antioxidant and anti-inflammatory modulating neurotrophic factors and promoting cell survival in a brain environment affected by substance consumption
It has been investigated that Omega 5 Nano PSO exerts its beneficial effects through various regulation and activation mechanisms in patients who consume psychoactive substances
1 Modulation of neurotrophic factors It has been suggested that Omega 5 can modify the levels of neurotrophic factors such as brain-derived neurotrophic factor BDNF and vascular endothelial growth factor VEGF in patients who consume psychoactive substances These factors play a crucial role in the neuroprotection and its modulation by Omega 5 could contribute to the improvement of cognitive status and cell survival in these patients
2 Antioxidant and anti-inflammatory action Omega 5 has been shown to have antioxidant and anti-inflammatory effects in several pathologies of the nervous system In patients who consume psychoactive substances who have high levels of neuroinflammation and oxidative stress Omega 5 can help reduce damage to neuronal and glial cells promoting cell survival and preserving a homeostatic brain environment
3 Protection against oxidative stress It has been suggested that Omega 5 may be useful to reduce the damage caused by oxidative stress at the brain level in substance abuse patients By acting as an antioxidant Omega 5 could counteract the negative effects of oxidative stress on brain cells and contribute to neuronal protection
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None