Ignite Creation Date:
2024-10-25 @ 7:51 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06633627
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-10-02
Brief Title:
Neurological Responses in Patients with Dentine Hypersensitivity
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Identification and Quantification of Neurological Responses in Patients with Dentine Hypersensitivity
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Dentine hypersensitivity also known as sensitive teeth is a common dental condition in which the dentine a layer of sensitive hard tissue under the enamel of the teeth becomes exposed making the teeth sensitive to stimuli such as hot and cold It poses a significant challenge for clinicians and affects patients quality of life
The overall aim of the study is to understand if a way of measuring brain activity electroencephalography EEG shows a response to tooth stimulation and see how these responses may be different in patients with dentine sensitivity
EEG records brain signals and can provide information about how the brain processes painful stimuli EEG recording is a non-evasive and painless procedure It involves using a cap with small sensors called electrodes to pick up brain signals During the EEG assessment appointment brain signals will be recorded throughout the duration when cold temperatures and short bursts of air are applied to the tooth Brain signals recorded during tooth stimulation from participants with and without dentine sensitivity will then be compared to explore if there are any differences
The investigators hope that EEG responses could be helpful to objectively assess dentine sensitivity further the understanding of brain processing of dental pain and allow the comparison of the effectiveness of different treatment options in the future
This information may help to improve treatments and the quality of life for patients with dentine sensitivity and potentially other types of dental pain
The overall aim of the study is to understand if a way of measuring brain activity electroencephalography EEG shows a response to tooth stimulation and see how these responses may be different in patients with dentine sensitivity
EEG records brain signals and can provide information about how the brain processes painful stimuli EEG recording is a non-evasive and painless procedure It involves using a cap with small sensors called electrodes to pick up brain signals During the EEG assessment appointment brain signals will be recorded throughout the duration when cold temperatures and short bursts of air are applied to the tooth Brain signals recorded during tooth stimulation from participants with and without dentine sensitivity will then be compared to explore if there are any differences
The investigators hope that EEG responses could be helpful to objectively assess dentine sensitivity further the understanding of brain processing of dental pain and allow the comparison of the effectiveness of different treatment options in the future
This information may help to improve treatments and the quality of life for patients with dentine sensitivity and potentially other types of dental pain
Detailed Description:
Dentine hypersensitivity DH is a common dental condition that has been defined as a short sharp pain arising from exposed dentine in response to stimuli typically thermal evaporative tactile osmotic or chemical and which cannot be ascribed to any other form of dental defect or pathology Many DH interventions have been investigated over the last 60 years but a lack of standardisation of pain measurement and objectivity of measures are major limitations for assessing the efficacy of products or understanding why products fail A potential solution to this problem is greater understanding of the pain propagation mechanism from controlled stimulus to objective measurable markers of pain severity
EEG electroencephalography is a non-invasive technique that measures the electrical activity of the brain using the electrodes placed on the scalp EEG provides information about the brains electrical activity over time helping diagnose and understand certain neurological conditions The investigators have carried out a number of studies using human dental pulp and other human tissue to further understand the mechanisms of pain including pulpal pain
Evoked potentials are EEG responses to specific stimuli such as light sound or heat Pain-evoked potentials from tooth pulp are evoked potentials specifically related to pain originating from the pulp of a tooth This type of measurement records the brains electrical response to a stimulus applied to a tooth such as thermal stimuli The resulting EEG recording can provide information about how the central nervous system processes painful stimuli including the speed and magnitude of the response It was hypothesised that EEG pain-evoked potentials if generated and measured in a controlled and repeatable way can potentially be used in conjunction with other diagnostic methods to objectively evaluate the severity of dentine sensitivity and compare the efficacy of different treatment options
EEG electroencephalography is a non-invasive technique that measures the electrical activity of the brain using the electrodes placed on the scalp EEG provides information about the brains electrical activity over time helping diagnose and understand certain neurological conditions The investigators have carried out a number of studies using human dental pulp and other human tissue to further understand the mechanisms of pain including pulpal pain
Evoked potentials are EEG responses to specific stimuli such as light sound or heat Pain-evoked potentials from tooth pulp are evoked potentials specifically related to pain originating from the pulp of a tooth This type of measurement records the brains electrical response to a stimulus applied to a tooth such as thermal stimuli The resulting EEG recording can provide information about how the central nervous system processes painful stimuli including the speed and magnitude of the response It was hypothesised that EEG pain-evoked potentials if generated and measured in a controlled and repeatable way can potentially be used in conjunction with other diagnostic methods to objectively evaluate the severity of dentine sensitivity and compare the efficacy of different treatment options
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None