Ignite Creation Date:
2024-10-25 @ 7:53 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06556420
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-30
Brief Title:
Analysis of Nasopharyngeal Microbiota in Patients With Respiratory Infections
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Analisi Del Microbiota Nasofaringeo in Pazienti Con Infezioni Respiratorie
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MINIPAR
Brief Summary:
Respiratory tract infections represent the most frequent infectious pathology in community environments and when of bacterial origin imply a morbid state generally supported by a pathogenic bacterial species predominant on the commensal flora of the airways Among the most frequent bacterial infections of the upper respiratory tract in pediatric age we find acute bacterial pharyngitis or pharyngotonsillitis caused by Streptococcus pyogenes β-hemolytic group A for which antimicrobial therapy is clearly indicated and which manifests itself with an onset sudden fever It should also be remembered that some forms of pharyngitis are caused by Chlamydia pneumoniae Mycoplasma pneumoniae Bordetella pertussis and Legionella commonly responsible for lower respiratory tract infections but recently also associated with upper respiratory tract infections In childhood a viral or bacterial infection of the upper respiratory tract in particular pharyngitis laryngitis can easily lead to an infection of the lower respiratory tract pneumonia In fact the inflammatory process triggered by a previous infection generally viral determines an impairment of mucociliary clearance which facilitates the proliferation not only of pathogenic bacteria but also of the commensal bacterial flora normally non-pathogenic An altered local microbial flora can therefore contribute to the pathogenesis of new infections or itself be responsible for invasive infections The microbiota of the upper airways may therefore be a further factor influencing the susceptibility frequency and severity of acute respiratory diseases The oropharyngeal microbiota is in fact made up of numerous bacterial species which by colonizing this anatomical tract interact with the mucosa of the pharynx and therefore with the immune system contributing to the homeostasis of the upper respiratory tract and consequently also preserving the integrity of the lower respiratory tract As observed for other anatomical sites the composition of the oropharyngeal microbiota is conditioned by external events among which we find the use of antibiotics or oral disinfectant drugs which can favor the development of pathogenic microorganisms Characterizing the oropharyngeal microbiota in a state of acute andor chronic respiratory infection could increase knowledge on the microbiological signature associated with such infections and ineffective antibiotic treatments Greater knowledge of it also with future corrective purposes as has now been demonstrated for other body areas could be of great help in reducing the risk of acute recurrent disease andor chronic consequences
Detailed Description:
In recent years the microbiota of the upper airways has emerged as a further factor influencing the susceptibility frequency and severity of acute respiratory diseases Greater knowledge of it also with corrective purposes as has now been demonstrated for other body areas could be of great help in reducing the risk of acute recurrent disease andor chronic consequences The oropharyngeal microbiota is in fact made up of numerous bacterial species which by colonizing this anatomical tract interact with the mucosa of the pharynx and therefore with the immune system contributing to the homeostasis of the upper respiratory tract and consequently also preserving the integrity of the lower respiratory tract As observed for other anatomical sites the composition of the oropharyngeal microbiota is conditioned by external events among which we find the use of antibiotics or oral disinfectant drugs which can favor the development of pathogenic microorganisms For this reason characterizing the oropharyngeal microbiota in a state of acute andor chronic respiratory infection could increase knowledge on the microbiological signature associated with such infections and ineffective antibiotic treatments to the point of becoming a factor used to prevent respiratory tract infections
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None