Ignite Creation Date:
2024-10-25 @ 7:53 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06540235
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-31
Brief Title:
The Effect of Bone-Conducted Stimulation on Rotary Chair Time Constants in Patients With Vestibular Migraines
Sponsor:
None
Organization:
None
Study Overview
Official Title:
VIBRANT-VM Vestibular Investigation of Bone-conducted Resonant Analysis of Time-constants in Patients With Vestibular Migraines
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
VIBRANT-VM
Brief Summary:
The goal of this clinical trial is to learn if the Otolith Labs device can improve vestibular function of subjects with vestibular migraine
The main questions it aims to answer are
When the Otolith Labs device is on are objective measures of the vestibular system better than when the device is off
When the Otolith Labs device is on are subjective measures of the vestibular system better than when the device is off
Are the objective measures related to the subjective measures
Researchers will change the order of the device settings to ensure the changes arent due to the order they are tested
Participants will
Wear the Otolith Labs device while in a rotary chair at different settings for different tests All of the rotary chair testing will take less than an hour
Answer questions about how the rotary chair testing made them feel for each test
Answer questions about their every-day susceptibility to motion sickness and about their vestibular migraine symptoms
The main questions it aims to answer are
When the Otolith Labs device is on are objective measures of the vestibular system better than when the device is off
When the Otolith Labs device is on are subjective measures of the vestibular system better than when the device is off
Are the objective measures related to the subjective measures
Researchers will change the order of the device settings to ensure the changes arent due to the order they are tested
Participants will
Wear the Otolith Labs device while in a rotary chair at different settings for different tests All of the rotary chair testing will take less than an hour
Answer questions about how the rotary chair testing made them feel for each test
Answer questions about their every-day susceptibility to motion sickness and about their vestibular migraine symptoms
Detailed Description:
This study is designed to investigate the effects of The Otolith Labs bone conduction device BCD on the vestibular system In the context of this trial the BCD was designed and developed to reduce the effects of external stimulation of the vestibular system The eventual intended use of the device is for people who have vestibular disorders eg Vestibular Migraine Menieres Disease who may benefit from a device that can provide a normalizing response to an abnormal vestibular neural signal
To better understand the functioning principles of the BCD the investigators want to conduct standard clinical testing using a rotary chair specifically
1 Step velocity testing SVT with the chair rotating and vision denied
2 Optokinetic testing OKT with the chair stationary and visual field moving
Published studies have demonstrated that a reduction in the vestibulo-ocular reflex VOR time constants during optokinetic and velocity step testing is correlated with improved motion sickness symptoms The investigators aim to determine if the BCD similarly reduces the VOR time constant A reduction in time constant has been shown to be strongly correlated with a reduced time constant of integration in the central velocity storage a long time constant very strongly correlates with motion sensitivity and with the severity of vestibular migraine episodes
In this study the BCD is set at one of three settings- turned off low power level high power level -while the participant is undergoing testing at 60 s patients own motion for step velocity testing or projected image for OKT The same test methodology and equipment shall be used for all participants In total 6 rotational tests - one clockwise rotation and one counterclockwise rotation at each of the three power settings and 6 static tests - with the visual field moving left then right at each of the three power settings will be conducted and the order of the highlow power settings will be randomized to the secondthird set of SVT and OKT The device is adjusted to a new power level a few seconds before initiating each SVT and OKT
Eye movements will be tracked during the SVT and OKT to evaluate decay in amplitudes and frequency of nystagmus over time typically around 15 seconds Comparison will be made between the three power conditions to evaluate the effect of bone conduction stimulation on the vestibular sense stimulated by rotation
The participant will be prompted to report on the Fast Motion Scale FMS - a simple validated 20 point verbally reported numerical rating scale - prior to and following each chair session to gauge the momentary level of motion sickness perception The FMS will be reported a total of 12 times per participant pre- post-rotary tests
Participants will complete the Motion Sickness Sensitivity Questionnaire Short Form MSSQ-SF to determine their history of sensitivity to provocative motion Participants will also complete the Vestibular Migraine Patient Assessment Tool and Handicap Inventory VM-PATHI to assess the correlation of the potential change in time constants and VOR gain to the perceived severity of their vestibular migraine condition
To better understand the functioning principles of the BCD the investigators want to conduct standard clinical testing using a rotary chair specifically
1 Step velocity testing SVT with the chair rotating and vision denied
2 Optokinetic testing OKT with the chair stationary and visual field moving
Published studies have demonstrated that a reduction in the vestibulo-ocular reflex VOR time constants during optokinetic and velocity step testing is correlated with improved motion sickness symptoms The investigators aim to determine if the BCD similarly reduces the VOR time constant A reduction in time constant has been shown to be strongly correlated with a reduced time constant of integration in the central velocity storage a long time constant very strongly correlates with motion sensitivity and with the severity of vestibular migraine episodes
In this study the BCD is set at one of three settings- turned off low power level high power level -while the participant is undergoing testing at 60 s patients own motion for step velocity testing or projected image for OKT The same test methodology and equipment shall be used for all participants In total 6 rotational tests - one clockwise rotation and one counterclockwise rotation at each of the three power settings and 6 static tests - with the visual field moving left then right at each of the three power settings will be conducted and the order of the highlow power settings will be randomized to the secondthird set of SVT and OKT The device is adjusted to a new power level a few seconds before initiating each SVT and OKT
Eye movements will be tracked during the SVT and OKT to evaluate decay in amplitudes and frequency of nystagmus over time typically around 15 seconds Comparison will be made between the three power conditions to evaluate the effect of bone conduction stimulation on the vestibular sense stimulated by rotation
The participant will be prompted to report on the Fast Motion Scale FMS - a simple validated 20 point verbally reported numerical rating scale - prior to and following each chair session to gauge the momentary level of motion sickness perception The FMS will be reported a total of 12 times per participant pre- post-rotary tests
Participants will complete the Motion Sickness Sensitivity Questionnaire Short Form MSSQ-SF to determine their history of sensitivity to provocative motion Participants will also complete the Vestibular Migraine Patient Assessment Tool and Handicap Inventory VM-PATHI to assess the correlation of the potential change in time constants and VOR gain to the perceived severity of their vestibular migraine condition
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None