Ignite Creation Date:
2024-10-25 @ 7:54 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06579508
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-20
Brief Title:
Effects of High-intensity Exercise With Hypoxia and Taurine Supplementation on Metabolic and Mitochondrial Parameters
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effects of High-intensity Intermittent Exercise With Recovery Hypoxia and Taurine Supplementation in Women With Obesity on Metabolic and Mitochondrial Parameters
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The prevalence of obesity in Brazil is one of the highest in Latin America As an inflammatory disease obesity needs to be treated and one of the best interventions is exercise This research aims to learn more about the effects of combining high-intensity training recovery hypoxia and taurine supplementation To better understand these effects the researchers will compare hypoxia and normoxia as well as taurine and placebo with all participants training in the same way The researchers will also investigate mitochondrial respiration and food consumption to connect certain aspects of obesity with overall health
Detailed Description:
Obesity is characterized by a chronic inflammatory state often linked with elevated oxidative stress and mitochondrial dysfunction While physical exercise can trigger inflammatory responses due to muscle damage it also promotes significant bodily adaptations particularly in body composition physical fitness and skeletal muscle tissue including enhanced mitochondrial dynamics Moderate hypoxia when combined with exercise further amplifies these benefits by increasing the expression of genes related to mitochondrial biogenesis GLUT1 expression and angiogenesis Previous findings suggest that high-intensity physical activity not only improves cardiorespiratory capacity and alters body composition but also significantly elevates inflammation Consequently taurine a supplement known for its anti-inflammatory properties and ability to reduce oxidative stress should be considered to mitigate these issues and optimize the benefits of exercise and hypoxia Based on these premises it is hypothesized that the combination of taurine supplementation with physical training under recovery hypoxia may reduce the significant rise in pro-inflammatory cytokines thereby enhancing the potential benefits of exercise and moderate hypoxia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None