Ignite Creation Date:
2024-10-25 @ 7:58 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06641739
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-10
Brief Title:
Photobiomodulation and Platelets Rich in Growth Factors PRGFs-Assisted Flap Surgery in Treating Stage III Periodontal Defects
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Comparative Clinical Trials of Laser Photobiomodulation and Platelets Rich in Growth Factors PRGFs-Assisted Flap Surgery in Treating Stage III Periodontal Defects an In-Depth Analysis of Clinical Outcomes and Healing Processes
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Stage 3 periodontitis is a condition marked by swift and severe destruction of periodontal tissues To effectively regenerate osseous defects resulting from periodontal disease it is crucial to leverage the intrinsic regenerative potential of the periodontium via meticulously formulated therapeutic strategies
Detailed Description:
The main treatment methods of periodontal diseases involve scaling and root planning SRP and periodontal surgery Periodontopathogens can penetrate deep by crossing the epithelial barrier which may be difficult to be remove by nonsurgical periodontal therapy NSPT alone A multitude of grafted and non-grafted approaches have been used in the management of Intra-bony defects However they do not provide predictable periodontal regeneration
A systematic review on the use of platelet-rich fibrin PRF for managing periodontal defects highlights its promising potential in periodontal regeneration It forms a fibrin matrix that promotes angiogenesis and enhances healing at defected sites The review emphasizes PRFs ability to sustain the release of growth factors which are crucial for osteoblastic proliferation migration and adherence This makes PRF an effective scaffold for cellular elements facilitating periodontal tissue regeneration
Laser photobiomodulation PBM has emerged as a promising adjunctive treatment as it stimulates cellular processes enhancing the natural regenerative capabilities of periodontal tissues Recent studies have demonstrated that PBM particularly with diode significantly improves clinical outcomes when combined with conventional periodontal treatments It promotes osteoblastic proliferation migration and adherence thereby facilitating bone regeneration and reducing periodontal pocket depth Additionally PBM enhances angiogenesis and modulates the release of growth factors creating an optimal healing environment
A systematic review on the use of platelet-rich fibrin PRF for managing periodontal defects highlights its promising potential in periodontal regeneration It forms a fibrin matrix that promotes angiogenesis and enhances healing at defected sites The review emphasizes PRFs ability to sustain the release of growth factors which are crucial for osteoblastic proliferation migration and adherence This makes PRF an effective scaffold for cellular elements facilitating periodontal tissue regeneration
Laser photobiomodulation PBM has emerged as a promising adjunctive treatment as it stimulates cellular processes enhancing the natural regenerative capabilities of periodontal tissues Recent studies have demonstrated that PBM particularly with diode significantly improves clinical outcomes when combined with conventional periodontal treatments It promotes osteoblastic proliferation migration and adherence thereby facilitating bone regeneration and reducing periodontal pocket depth Additionally PBM enhances angiogenesis and modulates the release of growth factors creating an optimal healing environment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None