Ignite Creation Date:
2024-10-25 @ 7:59 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06618469
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-09-18
Brief Title:
Effects of Resistance Training Programes At Different Intensities on Musculoskeletal Metabolic Lipid Immunological Inflammatory Well-being and Functional Parameters in Older Adults
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effects of Resistance Training Programes At Different Intensities on Musculoskeletal Metabolic Lipid Immunological Inflammatory Well-being and Functional Parameters in Older Adults
Status:
COMPLETED
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aging of the global population is recognized by the World Health Organization WHO as a major issue due to the disabilities and comorbidities related to this process with women being the gender most affected Due to the physiological and psychological age associated declines physical activity and exercise are proven strategies for reducing the impact of aging However it is still unknown what kind of training program could be the most effective in reversing deleterious age-related changes in older adults Regarding this the type of training intensity and exercise modality are two key training parameters in exercise programming and therefore different adaptations could be induced in older adults through the modification of these parameters Furthermore the type of training device is a significant factor and can act as a barrier or facilitator in older adults39 participation in physical activities and exercise programs Therefore the research project primary goals are to compare the effects of resistance training programes performed at different intensities and materials during 32 weeks on a variety of physiological parameters in older adults
Detailed Description:
This is a randomized clinical trial RCT with 6 parallel arms The subjects will be divided in 6 groups with a randomized technique assigned to a 32-week of a progressive elastic band-based resistance training program at high intensity HI b progressive elastic band-based resistance training program at moderate-high intensity MHI-bands c progressive elastic band-based resistance training program at moderate intensity MI d progressive elastic tubes-based resistance training program at moderate-high intensity MHI-tubes e progressive water-resistance training program at moderate intensity WMI f self-management control group CG The subjects will be submitted to a 2-session familiarization period and then a 32-week of training program will be performed twice a week
The exercise groups engaged in progressive elastic-based bands of tubes resistance training twice a week with three to four sets of six HI 10 MHI or 15 MI submaximal repetitions including six overall body exercises at a rate of perceived exertion RPE of 6-7 in the first four weeks and 8-9 in the remaining weeks on the OMNI-Resistance Exercise Scale RES The water-resistance group will perform similar exercises adapted to the water environment at maximal effort maximal speed in the concentric and eccentric phases of each repetition during 40 seconds Members of the control group were instructed to continue their everyday lives
Oxidative stress bone health body composition neuromuscular strength physical function quality of life lipidic immune and cardiometabolic profile will be assessed Oxidative stress status will be assessed in deoxyribonucleic acid DNA urinary 8-oxo-2-deoxyguanosine 8-oxo-dG lipids F2-isoprostanes8-iso-P malonaldehyde MDA and proteins protein carbonyls products together with antioxidant enzymes superoxide dismutase SOD and glutathione peroxidase GPx and thiol redox state reduced glutathione GSH oxidized glutathione GSSG and the GSSGGSH ratio Bone health will be integrated by measures of areal bone mineral density aBMD and the T-score of the lumbar spine L1-L4 segments L2-L4 segments and L1 L2 L3 and L4 individual vertebrae and proximal femur femoral neck trochanter intertrochanter Ward39s triangle and total hip in both projects will be assessed by dual-energy X-ray absorptiometry DXA Additionally bone health will be also composed by fracture risk the 10-year probability of a major osteoporotic fracture and the 10-year probability of a hip fracture bone turnover markers BTMs of bone formation procollagen type I N propeptide P1NP a bone-specific isoform of alkaline phosphatase bALP and bone resorption a β-isomerized form of C-terminal telopeptide of type I collagen β-CTx and their relationship bALP β-CTx ratio Body composition total body mass total fat mass total fat-free mass and total body fat percentage will be measured by DXA Moreover the neuromuscular strength of upper limbs elbow flexor and extensor muscles and lower limbs hip abductor and hip adductor along with knee flexor and extensor muscles will be assessed through isokinetic dynamometry at low 60s and high 180s velocities Finally physical performance will be measured using various functional tests and batteries widely used in the literature such as the 30 seconds chair stand 30sec-CS and 30 seconds arm curl 30sec-AC for muscle strengthendurance of the lower and upper limbs time up and go TUG for dynamic balanceagility the six-minute walking test 6MWT for aerobic endurance five sit-to stand
The exercise groups engaged in progressive elastic-based bands of tubes resistance training twice a week with three to four sets of six HI 10 MHI or 15 MI submaximal repetitions including six overall body exercises at a rate of perceived exertion RPE of 6-7 in the first four weeks and 8-9 in the remaining weeks on the OMNI-Resistance Exercise Scale RES The water-resistance group will perform similar exercises adapted to the water environment at maximal effort maximal speed in the concentric and eccentric phases of each repetition during 40 seconds Members of the control group were instructed to continue their everyday lives
Oxidative stress bone health body composition neuromuscular strength physical function quality of life lipidic immune and cardiometabolic profile will be assessed Oxidative stress status will be assessed in deoxyribonucleic acid DNA urinary 8-oxo-2-deoxyguanosine 8-oxo-dG lipids F2-isoprostanes8-iso-P malonaldehyde MDA and proteins protein carbonyls products together with antioxidant enzymes superoxide dismutase SOD and glutathione peroxidase GPx and thiol redox state reduced glutathione GSH oxidized glutathione GSSG and the GSSGGSH ratio Bone health will be integrated by measures of areal bone mineral density aBMD and the T-score of the lumbar spine L1-L4 segments L2-L4 segments and L1 L2 L3 and L4 individual vertebrae and proximal femur femoral neck trochanter intertrochanter Ward39s triangle and total hip in both projects will be assessed by dual-energy X-ray absorptiometry DXA Additionally bone health will be also composed by fracture risk the 10-year probability of a major osteoporotic fracture and the 10-year probability of a hip fracture bone turnover markers BTMs of bone formation procollagen type I N propeptide P1NP a bone-specific isoform of alkaline phosphatase bALP and bone resorption a β-isomerized form of C-terminal telopeptide of type I collagen β-CTx and their relationship bALP β-CTx ratio Body composition total body mass total fat mass total fat-free mass and total body fat percentage will be measured by DXA Moreover the neuromuscular strength of upper limbs elbow flexor and extensor muscles and lower limbs hip abductor and hip adductor along with knee flexor and extensor muscles will be assessed through isokinetic dynamometry at low 60s and high 180s velocities Finally physical performance will be measured using various functional tests and batteries widely used in the literature such as the 30 seconds chair stand 30sec-CS and 30 seconds arm curl 30sec-AC for muscle strengthendurance of the lower and upper limbs time up and go TUG for dynamic balanceagility the six-minute walking test 6MWT for aerobic endurance five sit-to stand
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None