Ignite Creation Date:
2024-10-25 @ 8:00 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06518083
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-11
Brief Title:
The Relation Between Triglyceride- Glucose Index Procalcitonin and Cardiac Affection in Septic Shock
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Relation Between Dynamic Change in Triglyceride- Glucose Index Procalcitonin and Cardiac Affection in Patients Admitted to the Intensive Care Unit With Septic Shock
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study is carried out to demonstrate the relation between Triglyceride -glucose index and cardiac affection in the patients admitted to the ICU with septic shock
Detailed Description:
Sepsis a condition characterized by a dysregulated immune response to infection is a prominent contributor to global mortality1
Insulin resistance IR is typified by reduced insulin sensitivity in peripheral tissues and is linked to various pathological conditions 2 The triglyceride-glucose TyG index recognized as a surrogate marker of insulin resistance has recently gained attention as a potential prognostic tool for various metabolic and cardiovascular diseases 3 Preliminary investigations have revealed a correlation between metabolic disorders characterized by dysregulated lipid and glucose metabolism and the severity of sepsis Notably a high TyG index has been associated with increased in-hospital mortality in sepsis patients 4 studies only focused on the initial TyG value within the first 24 h of ICU admission and did not consider the dynamic changes in this marker over time As insulin sensitivity in critically ill patients can change over time 5 6 It is possible that the TyG variability ratio TyGVR during hospital stay may be a better marker for adverse long-term prognosis and could be used for early risk stratification in critically ill patients Procalcitonin PCT is produced during bacterial infections sepsis cardiogenic shock major surgery burns multiple trauma and after cardiac surgery 78
In this study we will discuss the relation between dynamic changes in both TyG index procalcitonin and cardiac affection in the ICU patients admitted with septic shock
Insulin resistance IR is typified by reduced insulin sensitivity in peripheral tissues and is linked to various pathological conditions 2 The triglyceride-glucose TyG index recognized as a surrogate marker of insulin resistance has recently gained attention as a potential prognostic tool for various metabolic and cardiovascular diseases 3 Preliminary investigations have revealed a correlation between metabolic disorders characterized by dysregulated lipid and glucose metabolism and the severity of sepsis Notably a high TyG index has been associated with increased in-hospital mortality in sepsis patients 4 studies only focused on the initial TyG value within the first 24 h of ICU admission and did not consider the dynamic changes in this marker over time As insulin sensitivity in critically ill patients can change over time 5 6 It is possible that the TyG variability ratio TyGVR during hospital stay may be a better marker for adverse long-term prognosis and could be used for early risk stratification in critically ill patients Procalcitonin PCT is produced during bacterial infections sepsis cardiogenic shock major surgery burns multiple trauma and after cardiac surgery 78
In this study we will discuss the relation between dynamic changes in both TyG index procalcitonin and cardiac affection in the ICU patients admitted with septic shock
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None