Ignite Creation Date:
2024-10-25 @ 8:00 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06561724
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-04-09
Brief Title:
Diet Supplementation With Prebiotics to Improve Gut Health in Egyptian Children
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Application of Potential Biotechnologies to Develop Novel Probiotics Functional Food Products With High Viability for Modulating the Gut Microbiome Among Healthy and Under Stress Subiects
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study described herein seeks to assess the extent to which diet supplementation of young Egyptian children one of the most vulnerable groups to the risk of diarrhea with prebiotic fiber can improve their gut health
Detailed Description:
The gastrointestinal tract GI is an indispensable organ for any human In addition to digesting and extracting nutrients from consumed foods it also houses the largest community of human-associated microbes called human gut microbiota plays a role in immune system development and modulation participates in water and electrolyte balancing and excretes waste products Because the human gut is constantly affected by external stimuli and foreign objects via food ingestion it is not surprising that GI tract diseases and especially diarrheal disease are one of the most common causes of human illness Diarrhea is especially prevalent at younger age and indeed many young Egyptian children are vulnerable to develop such illness
Healthy GI tract is the most densely populated human-associated microbial habitat and harbors a highly diverse microbial community This gut microbiota functions as an essential organ in nutrition immunity and physiology of human hosts Gut microbes are responsible for polysaccharide hydrolysis vitamin production immune system stimulation and modulation of gut motility While healthy gut microbiome provides protection of the human host against pathogen invasion microbiota disbalance opens doors for the host to be colonized by intestinal pathogens including viruses virulent bacteria and parasites which all can cause diarrhea The burden of gut infections is high in Egypt especially among young children The vulnerability of these groups to gut infections has been linked previously to the level of hygiene and the integrity of intestinal barrier function and can also be associated with the prevalence of pathogenic microbes in consumed foods such as poultry The consumption of contaminated food and water poor health knowledge and ineffective infection control programs are contributing considerably to the persistence of enteric infections
One of the approaches to reduce the prevalence of intestinal infections and resulting diarrhea is to improve overall gut health by promoting the development of healthy gut microbiota and strengthening gut barrier function Many dietary components can affect the composition and function of human gut microbiome Among these dietary fiber constitutes a variety of polysaccharides that are largely undigested and unabsorbed by humans who lack enzymes required to break them but are readily degraded by microbes in the large bowel Fiber species that are selectively utilized by microbes and provide health benefits to the host are called prebiotics These prebiotic fibers such as inulin selectively promote growth and expansion of beneficial members of our gut community thus making it harder for pathogens to establish themselves in the gut Fiber degradation by resident gut microbes also increases the levels of beneficial short chain fatty acids SCFAs which were shown to improve gut barrier function and reduce tissue inflammation
Healthy GI tract is the most densely populated human-associated microbial habitat and harbors a highly diverse microbial community This gut microbiota functions as an essential organ in nutrition immunity and physiology of human hosts Gut microbes are responsible for polysaccharide hydrolysis vitamin production immune system stimulation and modulation of gut motility While healthy gut microbiome provides protection of the human host against pathogen invasion microbiota disbalance opens doors for the host to be colonized by intestinal pathogens including viruses virulent bacteria and parasites which all can cause diarrhea The burden of gut infections is high in Egypt especially among young children The vulnerability of these groups to gut infections has been linked previously to the level of hygiene and the integrity of intestinal barrier function and can also be associated with the prevalence of pathogenic microbes in consumed foods such as poultry The consumption of contaminated food and water poor health knowledge and ineffective infection control programs are contributing considerably to the persistence of enteric infections
One of the approaches to reduce the prevalence of intestinal infections and resulting diarrhea is to improve overall gut health by promoting the development of healthy gut microbiota and strengthening gut barrier function Many dietary components can affect the composition and function of human gut microbiome Among these dietary fiber constitutes a variety of polysaccharides that are largely undigested and unabsorbed by humans who lack enzymes required to break them but are readily degraded by microbes in the large bowel Fiber species that are selectively utilized by microbes and provide health benefits to the host are called prebiotics These prebiotic fibers such as inulin selectively promote growth and expansion of beneficial members of our gut community thus making it harder for pathogens to establish themselves in the gut Fiber degradation by resident gut microbes also increases the levels of beneficial short chain fatty acids SCFAs which were shown to improve gut barrier function and reduce tissue inflammation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None