Ignite Creation Date:
2024-10-25 @ 8:01 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06591858
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-05
Brief Title:
Evaluation of Renal Function in Patients With Hyperthyroidism
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Evaluation of Renal Function in Patients With Subclinical and Overt Hyperthyroidism
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate the effect of subclinical and overt Hyperthyroidism in renal function
Detailed Description:
Thyroid disorders are very common with a high prevalence among the general population Thyroid diseases are associated with many detrimental effects that have a serious impact on various body systems1
Hyperthyroidism can be overt or subclinical Overt hyperthyroidism is defined as low serum thyroid stimulating hormone TSH and elevated serum thyroxin T4 tri-iodothyronine T3 or both Whereas subclinical hyperthyroidism SCH is defined as low serum TSH level with normal serum levels of T3 and T42
The relationship between thyroid hormones and kidney function is well-known for many years Thyroid diseases adversely affect renal physiology meanwhile kidney diseases could result in thyroid dysfunction
Thyroid hormones contribute to the maintenance of water and electrolyte balance and participate in the renal transport system Hyperthyroidism results in an increased glomerular filtration rate GFR by about 18-25 due to increased renal blood flow and activation of renin angiotensin-aldosterone system RAAS Also these changes have been reported in patients with hyperthyroidism3-5
Several mechanisms were found playing roles on increasing both the size and functional capacity of kidney
1 Thyroid hormone directly influences the expression and activity of most of renal transporters by direct binding of thyroid hormone to the promoter region of a transporter gene 6
2 In hyperthyroid state beta-adrenergic receptors in kidney cortex and synthesis and secretion of renin by juxtaglomerular cells are increased which in turn enhance angiotensin-converting enzyme activity7
3 Increased RAAS activity results in afferent arteriolar vasodilatation and efferent arteriolar vasoconstriction with a consequent increase in the filtration pressure8 D Hyperthyroidism increases systolic blood pressure by increasing heart rate decreasing systemic vascular resistance raising cardiac output and increases nitric oxide production which all contributes to the hyper dynamic circulation Hyperthyroidism results in increased renal blood flow7
Observed that both BUN and creatinine levels increased significantly after euthyroidism was achieved in hyperthyroid patients these findings point out to true decline in renal function rather than a mere adaptation to hemodynamic changes
Although the mechanistic link between thyroid and kidney disease remains unclear hyperthyroidism may have significant effect on renal function
Hyperthyroidism can be overt or subclinical Overt hyperthyroidism is defined as low serum thyroid stimulating hormone TSH and elevated serum thyroxin T4 tri-iodothyronine T3 or both Whereas subclinical hyperthyroidism SCH is defined as low serum TSH level with normal serum levels of T3 and T42
The relationship between thyroid hormones and kidney function is well-known for many years Thyroid diseases adversely affect renal physiology meanwhile kidney diseases could result in thyroid dysfunction
Thyroid hormones contribute to the maintenance of water and electrolyte balance and participate in the renal transport system Hyperthyroidism results in an increased glomerular filtration rate GFR by about 18-25 due to increased renal blood flow and activation of renin angiotensin-aldosterone system RAAS Also these changes have been reported in patients with hyperthyroidism3-5
Several mechanisms were found playing roles on increasing both the size and functional capacity of kidney
1 Thyroid hormone directly influences the expression and activity of most of renal transporters by direct binding of thyroid hormone to the promoter region of a transporter gene 6
2 In hyperthyroid state beta-adrenergic receptors in kidney cortex and synthesis and secretion of renin by juxtaglomerular cells are increased which in turn enhance angiotensin-converting enzyme activity7
3 Increased RAAS activity results in afferent arteriolar vasodilatation and efferent arteriolar vasoconstriction with a consequent increase in the filtration pressure8 D Hyperthyroidism increases systolic blood pressure by increasing heart rate decreasing systemic vascular resistance raising cardiac output and increases nitric oxide production which all contributes to the hyper dynamic circulation Hyperthyroidism results in increased renal blood flow7
Observed that both BUN and creatinine levels increased significantly after euthyroidism was achieved in hyperthyroid patients these findings point out to true decline in renal function rather than a mere adaptation to hemodynamic changes
Although the mechanistic link between thyroid and kidney disease remains unclear hyperthyroidism may have significant effect on renal function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None