Ignite Creation Date:
2024-10-25 @ 8:01 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06632041
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-06
Brief Title:
Necrotizing Enterocolities
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Haematological Disturbances in Neonates with Necrotizing Enterocolities
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Haematological disturbances in neonates with necrotizing enterocolities
Detailed Description:
Necrotizing enterocolitis NEC is an acquired multifactorial and devastating gastrointestinal disease associated with high morbidity and mortality in preterm neonates With an incidence of about 7 in infants with BW lt 1500 g and mortality up to 30 NEC presents as a medical and surgical emergency It is characterized by ischemia necrosis and inflammation of bowel wall with invasion by gas-forming organisms and intramural dissection of gas characteristicall appearing as pneumatosis intestinalis in radiological and pathological studies While exact etiology is undetermined the pathogenesis is believed to be an anomalous innate immune response to an altered less diverse intestinal microbiota by the highly immunoreactive enterocytes of premature infants leading to inflammation and tissue necrosis
in this devastating disease with undetermined etiology Breast milk feeding prolonging gestation to avoid prematurity antenatal steroid and the use of probioticsprebiotics are established prevention strategies in NEC
The hematological abnormalities associated with NEC were first described 25 years ago by Hutter et alThe abnormalities observed in a series of 40 patients with NEC included thrombocytopenia with
and without disseminated intravascular coagulation DIC neutrophilia or neutropenia and hemolytic anemia
in this devastating disease with undetermined etiology Breast milk feeding prolonging gestation to avoid prematurity antenatal steroid and the use of probioticsprebiotics are established prevention strategies in NEC
The hematological abnormalities associated with NEC were first described 25 years ago by Hutter et alThe abnormalities observed in a series of 40 patients with NEC included thrombocytopenia with
and without disseminated intravascular coagulation DIC neutrophilia or neutropenia and hemolytic anemia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None