Ignite Creation Date:
2024-10-25 @ 8:02 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06584565
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-26
Brief Title:
A Multicenter Study Based on Multi-omics Analysis to Predict the Early Prognosis and Recurrence Risk of Acute Ischemic Stroke
Sponsor:
None
Organization:
None
Study Overview
Official Title:
A Multicenter Study Based on Multi-omics Analysis to Predict the Early Prognosis and Recurrence Risk of Acute Ischemic Stroke
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Through a multicenter prospective AIS cohort study we analyze the potential association of human proteome microbiome and metabolome alterations with AIS prognosis searching for key proteins differential organisms and metabolites combining experimental data at multiple molecular levels with computational models and establishing early prediction models through machine learning-based prediction algorithms While closely tracking the recurrence of stroke in AIS patients we evaluate the predictive value of human proteome microbiome and metabolites for stroke recurrence through a nested case-control study which provides key reference information for exploring the unknown residual risk of AIS recurrence
Detailed Description:
Currently the burden of brain vascular disease in China is the highest in the world and among them the incidence rate of acute ischemic stroke AIS is high the recurrence rate is high the disability rate is high the mortality rate is high and the social burden is heavy With the increasing number of AIS patients how to effectively prevent and treat them is a huge challenge facing us The occurrence and development of AIS are caused by the joint action of multiple risk factors and mutual influence and single technical means are difficult to deeply explore its complex mechanism Therefore building a risk prediction model for poor prognosis and recurrence based on multi-omics technology and layering risk factors for patients are the important research directions for the future This study aims to establish a multi-center cohort by collecting fecal and blood samples from AIS patients and conducting proteomic microbial and metabolomic detection It records the prognosis and recurrence events and uses cross-omics analysis technology to explore the multi-omics network molecular mechanism and screen for new intervention targets It establishes an early prediction model and explores the stroke secondary prevention strategy based on multi-omics data
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None